Banca de DEFESA: Marina Lima Rodrigues

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : Marina Lima Rodrigues
DATE: 20/12/2022
TIME: 09:00
LOCAL: Videoconferência
TITLE:

NATURAL AND SYNTHETIC POLYMER NANOPARTICLES CONTAINING LATEX FROM EUPHORBIA TIRUCALLI: PRODUCTION, CHARACTERIZATION AND ANTINOCICETIVE ACTION

KEY WORDS:

Euphorbia tirucalli; nanoparticles; anti-inflammatory; physicochemical.

PAGES: 115
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Euphorbia tirucalli L. is a plant that has in its latex the compound eufol which, when highly diluted, has several medicinal properties, such as anti-inflammatory, contraceptive and antitumor. The application of nanotechnology to herbal medicines and plant extracts can enhance the action of plant extracts, promote the sustained release of active principles, reduce the necessary dose and side effects, through the encapsulation of drugs, being an adequate strategy to overcome resistance mechanisms cell and increase drug selectivity by site-specific. The delivery of nanoparticles has to meet several requirements for clinical applications, with the objective of greater standardization, approval and acceptance in relation to legislation, in which in this work the preparation of nanoparticles with chitosan and PLGA, evaluation of physical-chemical parameters and and in vivo test. Particles containing the latex, high encapsulation efficiency (> 90%), with a release profile at acidic pH, slow and constant for 6 hours. Through the dynamic light scattering technique it was verified that the mean of the nanoparticles with the drug has a diameter close to 611 nm, with a good polydispersion index of 0.146 and a zeta potential value (2-± 23 mV). In FTIR spectroscopy, as chitosan nanoparticles dissipated at 1.566 cm-1, weak band of angular deformation used to characterize secondary amines and amides. Evaluation of the wavelength shift of the eufol latex at different pHs separated all in the range from 200 to 220 nm. In the in vivo hypernociception assay, latexeufol and nanoparticles containing eufol significantly inhibited the mechanical hypernociception induced by carrageenan.

BANKING MEMBERS:
Externo à Instituição - ODAIR ATONIO BARBIZAN
Externa à Instituição - AMANDA DE CARVALHO PEREIRA MORAES
Presidente - 1644041 - CLAURE NAIN LUNARDI GOMES
Interno - 1652361 - MARCELO HENRIQUE SOUSA
Externo ao Programa - 1774553 - PAULO GUSTAVO BARBONI DANTAS NASCIMENTO