Banca de DEFESA: David Alves de Araujo Junior

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : David Alves de Araujo Junior
DATE: 26/06/2024
TIME: 14:00
LOCAL: Plataforma TEAMS
TITLE:

NEUROIMAGING ASSESSMENT OF PEDIATRIC ENCEPHALIC CHANGES RELATED TO SARS-CoV-2 INFECTION DURING PREGNANCY

KEY WORDS:

COVID, SARS-CoV-2, pregnancy, neonatology, ultrasound, elastography, neuroimaging.

PAGES: 169
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Background: SARS-CoV-2 infection and perinatal neurological outcomes are still not completely understood. However, there is recent evidence of white matter disease and impaired neurodevelopment in newborns after maternal SARS-CoV-2 infection. These appear to occur as consequence of both direct viral effects and systemic inflammatory response, with glial cells / myelin involvement and regional hypoxia / microvasculature disruption. We sought to characterize consequences of the maternal and fetal inflammatory condition in the central nervous system of newborns post SARS-CoV-2 maternal infection. Methods: We conducted a longitudinal prospective cohort study, from June 2020 to December 2021, with follow-up of newborns from mothers exposed or not exposed to SARS-CoV-2 infection during pregnancy. Brain analysis included data from cranial ultrasound scan (CUS) with grayscale, Doppler studies (color and spectral), and ultrasound-based brain elastography (shear-wave mode), in specific regions of interest (ROIs): deep white matter, superficial white matter, corpus callosum, basal ganglia, and cortical grey matter. Brain elastography was used for estimation of brain parenchymal stiffness, which is an indirect quantifier for myelin cerebral tissue content. Results: A total of 219 single-pregnancy children were enrolled, including 201 from mothers exposed to SARS-CoV-2 infection and 18 from unexposed controls. Neuroimaging evaluation was performed at 6 months of adjusted chronological age, and it demonstrated 18 grayscale and 21 Doppler abnormal exams. Predominant findings were hyper echogenicity of deep brain white matter and basal ganglia (caudate nuclei / thalamus), and reduction in resistivity and pulsatility index of intracranial arterial flow. Anterior brain circulation (middle cerebral and pericallosal arteries) displayed wider range of flow variation than posterior circulation (basilar artery). Shear-wave US elastography analysis demonstrated reduction of stiffness values in SARS-CoV-2 exposed group at all analyzed regions of interest, especially in the deep white matter elasticity coefficients (3.98 ± 0.62) compared to control group (7.76 ± 0.77); pvalue<0.001. Conclusion: This study further characterizes pediatric structural encephalic changes associated with SARS-CoV-2 infection during pregnancy. Maternal infection has shown to be related to cerebral deep white matter predominant involvement, with regional hyper echogenicity and reduction of elasticity coefficients, suggesting zonal impairment of myelin content. Morphological findings may be subtle, and functional studies such as Doppler and elastography may be a valuable tool for identifying more accurately which infants are at risk of neurological damage.

COMMITTEE MEMBERS:
Externo à Instituição - FRANCISCO ABAETÉ DAS CHAGAS NETO - USP-RB
Interna - 2731816 - JULIANA FORTE MAZZEU DE ARAUJO
Presidente - ***.774.921-** - LICIA MARIA HENRIQUE DA MOTA - UnB
Externa à Instituição - NATÁLIA TORRES GIACOMIN PITMAN - USP
Externa à Instituição - NORMA SELMA SANTOS COSTA - USP