Banca de DEFESA: André Araújo de Medeiros Silva

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : André Araújo de Medeiros Silva
DATE: 29/09/2023
TIME: 14:00
LOCAL: Auditório I do Hospital Universitário de Brasília
TITLE:

ESTUDO DA APRESENTAÇÃO CLÍNICA, DO ESTADIO PATOLÓGICO E DOS RESULTADOS ONCOLÓGICOS DO CÂNCER COLORRETAL NO ADULTO JOVEM

KEY WORDS:

Keywords: colorectal cancer, young adult, clinical presentation, pathological staging, oncological treatment, oncological results.

PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Background: Colorectal cancer is the second most common and deadliest tumor around the world. In recent decades, the incidence of colorectal cancer has progressively increased among young patients. Previous analyzes have shown that colorectal cancer in this population has a worse prognosis due to more aggressive characteristics and more advanced stages at the time of diagnosis. However, these findings are not uniform across different parts of the globe. Objective: To evaluate the effect of age on the clinical presentation, pathological staging, therapy and oncological outcomes of colorectal cancer. Methods: The medical records of 434 patients with colorectal adenocarcinoma were reviewed. Patients were divided into two groups according to age. The young group (age < 50 years) consisted of 78 patients, and the older group (age ≥ 50 years) consisted of 356 patients. Clinical variables, time interval between onset of symptoms and diagnosis, pathological stage, operative mortality and oncological stages were compared between groups. Results: The average follow-up in months was 35.59 ± 16.27. Age was an independent factor for longer hospital stays in patients > 50 years old [PR = 0.11 (95% CI: 0.01; 0.21), p = 0.0336]. Patients < 50 years old had more undifferentiated histological types > 50 years old [PR= 2.38 (95% CI: 1.18; 4.78; p = 0.0147)]. There were no other differences on surgical and clinical presentation and oncological outcome. Conclusion: Young patients have a higher frequency of undifferentiated tumors. Age has not been shown to impact oncological outcomes.

COMMITTEE MEMBERS:
Externo à Instituição - HÉLIO MOREIRA JÚNIOR - UFG
Presidente - 2222541 - JOAO BATISTA DE SOUSA
Externo à Instituição - MARCELO DE MELO ANDRADE COURA - SESDF
Interno - ***.355.041-** - PAULO GONCALVES DE OLIVEIRA - USP