Banca de QUALIFICAÇÃO: MARIA EDUARDA CANELLAS DE CASTRO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARIA EDUARDA CANELLAS DE CASTRO
DATE: 01/09/2023
TIME: 10:30
LOCAL: PLATAFORMA ONLINE
TITLE:

DEVELOPMENT OF CHILDREN EXPOSED TO SARS-COV-2 DURING PREGNANCY – A PROSPECTIVE ANALYSIS

KEY WORDS:

Intrauterine exposure; SARS-CoV-2; Child development.

PAGES: 20
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction: Little is known about the effects of intrauterine exposure to SARS-CoV-2, especially on neurodevelopment in children. Objective: To verify the effect of intrauterine exposure to SARS-CoV-2 on child development. Methods: Children of mothers who had SARS-CoV-2 infection during pregnancy (attested by RT-PCR of nasopharyngeal swabs) were evaluated in prospective and analytical outpatient consultations carried out periodically after delivery. Development was assessed with NBAS (Neonatal Behavioral Assessment Scale de Brazelton) and Bayley-III Scales using a cutoff threshold set at >85. Differences between groups were assessed by analysis of variance using a Tukey post hoc test. Results: 262 exposed children were followed up. An amount of 97 were assessed using the NBAS scale, which showed a lower total score in newborns of mothers with a critical condition of infection (p<0.05), as well as a significant change in the social interaction category (p<0.05). At 6 and 12 months, 110 and 94 children were submitted to the Bayley III Scale and the highest levels of risk of delay were in the domain of language, with a higher frequency of delay in this regard at 12 months. The cognitive domain showed worse performance at 6 months when compared to 12 months (p<0.05). Conclusions: Pregnant women infected in the third trimester or at the time of delivery had more severe conditions and their children had lower performance in the developmental assessment. Children's performance at 6 months in the cognitive domain was worse when compared to 12 months.

COMMITTEE MEMBERS:
Presidente - ***.432.421-** - ALEXANDRE ANDERSON DE SOUSA MUNHOZ SOARES - UNICAMP
Interno - ***.583.131-** - LUIZ SÉRGIO FERNANDES DE CARVALHO - UNICAMP
Externa à Instituição - MARTA DAVID ROCHA DE MOURA
Externa à Instituição - TATIANA BARCELOS PONTES