Banca de DEFESA: Raysa Hellen Assuncao Costa

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Raysa Hellen Assuncao Costa
DATE: 22/07/2022
TIME: 13:00
LOCAL: Plataforma Teams
TITLE:

Facial dystonias and botulinum toxin. the negative impact on latency after multiple doses

KEY WORDS:

Blepharospasm; Hemifacial Spasm ;Botulinum Toxin;

PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Blepharospasm, hemifacial spasm and facial dystonia are a group of diseases characterized by involuntary muscle spasms that produce abnormal movements, usually treated with botulinum toxin applications. The objective of this study was to evaluate the effectiveness of treatment with botulinum toxin type A in 3 groups of patients with facial dystonia, verifying the latency after application and the duration of the drug's effect, taking into account the possible effect of tolerance in those who used multiple previous doses of this medication. Materials and methods: patients were divided into 3 groups: group A composed of 7 treatment-naïve individuals; Group B with 15 patients submitted to less than 3 previous applications; and group C with 10 patients submitted to more than 4 previous applications, totaling 32 participants in the research. Results: there was a lower latency in the treatment-naïve group, with statistical significance. However, regarding the duration of the effect and effective time, there was no statistical difference between the groups. Conclusion: therefore, TBA is considered an effective drug both in treatment-naïve patients and in people undergoing multiple doses, but with a faster onset of action and, consequently, symptom resolution in a shorter time in treatment-naïve patients.

BANKING MEMBERS:
Presidente - 2647517 - RIVADAVIO FERNANDES BATISTA DE AMORIM
Interno - 2676451 - CIRO MARTINS GOMES
Externa ao Programa - 1217226 - MARIA REGINA CATAI CHALITA
Externo à Instituição - LUCIENE BARBOSA DE SOUSA - UNIFESP