Banca de DEFESA: Luiz Gustavo Piroli Cabral

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Luiz Gustavo Piroli Cabral
DATE: 29/11/2022
TIME: 14:00
LOCAL: fav
TITLE:

Safety test of the intravenous use of allogeneic mesenchymal stem cells in 

domestic cats

KEY WORDS:

cats

steam cells

safety

PAGES: 30
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Over the years, felines have gained increasing acceptance as pets, which is reflected in the growth

of the population of these pets (RECHE JUNIOR 2018). The use of stem cells, also called cell therapy, has great potential for

applicability to feline diseases, but there are still several questions to be answered regarding its use, including its 

safety(QUIMBY 2018). Thus, the present study aimed to evaluate the safety of using halogenated mesenchymal

stem cells(MSCs) intravenously by monitoring physical parameters (mucosal staining, lymph node examination, 

heart and respiratory rate, rectal temperature). and hematology of a group of 8 healthy cats. Applications were 

carried out atthe Clinic School of Veterinary Medicine of FACISA to monitor possible adverse reactions. Among the 

physical parameters evaluated previously and throughout the study, no relevant changes were observed. As for the 

hematological parameters, the results indicate that in the first week, the only parameter whose average showed a 

significant reduction was Alkaline Phosphatase. Two weeks after the application of CTM, three parameters showed a

significant reduction in the average in relation to the levels observed before the beginning of the experiment, which

are Hematocrit, Hemoglobin and Creatinine. After 3 weeks of MSC application, all parameters returned to levels 

close to the original values. The present study points to the safety of using allogeneic MSCs intravenously in cats at

the established dose.

BANKING MEMBERS:
Presidente - 1765666 - FABIO HENRIQUE BEZERRA XIMENES
Interna - 3000776 - LIRIA QUEIROZ LUZ HIRANO
Externa à Instituição - Hilana dos Santos Sena Brunel