Banca de DEFESA: ANNA CLARA DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNA CLARA DOS SANTOS
DATE: 27/11/2023
TIME: 14:00
LOCAL: Laboratório de Anatomia Veterinária
TITLE:

CHRONIC KIDNEY DISEASE IN CATS – BIOCHEMICAL PARAMETERS AND PARATHORMONE

KEY WORDS:

CKD, PTH, cats

PAGES: 38
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Veterinária
SUMMARY:

Chronic Kidney Disease (CKD) is prevalent in elderly cats, often manifesting itself stably over long periods. Identifying parameters signaling the progression of CKD is crucial for early and efficient diagnosis, thereby improving patient prognosis. The objective of this study was to assess whether there is a relationship between parathyroid hormone and other biochemical parameters in cats with chronic kidney disease in stages 2, 3, and 4. Fifteen adult cats, 12 males, and 3 females, were evaluated and divided into three groups: Group II (n=9), Group III (n=3), and Group IV (n=3). All cats underwent anamnesis and physical examination, considering weight, body condition score, age, and breed. For all groups, parathyroid hormone, hematocrit, calcium, phosphorus, urea, creatinine, potassium, systolic blood pressure, and time of survival after diagnosis were assessed. Results indicated that systolic blood pressure was above ideal values. Body condition score varied significantly between groups, highlighting different levels of impairment. Hematometric values remained within normal limits, while ionic calcium varied, indicating possible renal compromise. Phosphorus was elevated in one CKD group, and urea and creatinine showed significant increases in affected groups. Parathyroid hormone (PTH) was elevated in one CKD group. Statistical differences were evident for urea between Group II and Group IV and for creatinine between Group II and Group IV and Group III and Group IV. Correlation analysis did not reveal statistical differences, but variations in correlation coefficients suggested associations between different parameters in the studied groups. The study analyzed the percentage of deaths in cats with chronic kidney disease (CKD), indicating its relation to the severity of the condition and determination of survival. Results revealed that in Group II, the majority of deaths occurred within an interval of 4 to 48 months, affecting 44.44% of the animals. In Group III, all cats died within a period of 16 to 65 months after the diagnosis of CKD. In Group IV, 66.67% of cats died within an interval of 26 to 54 months. In summary, the study provided a comprehensive understanding of the factors involved in the progression of CKD in cats, highlighting the complexity of the disease and the need for a multifaceted approach in diagnosis and treatment.

COMMITTEE MEMBERS:
Presidente - 2474273 - EDUARDO MAURICIO MENDES DE LIMA
Interna - 2324672 - ANGELA PATRICIA SANTANA
Interno - 1307139 - FABIANO JOSE FERREIRA DE SANT ANA
Interno - 1713966 - MARCELO ISMAR SILVA SANTANA
Externa ao Programa - 2314995 - CHRISTINE SOUZA MARTINS - UnBExterno à Instituição - ANDRE RODRIGUES DA CUNHA BARRETO VIANNA - UFPR