Banca de DEFESA: Samuel Freitas Bastos

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Samuel Freitas Bastos
DATE: 28/11/2022
TIME: 14:00
LOCAL: FAV
TITLE:

EVALUATION OF THE CLINICAL EFFECTIVENESS OF TISSUE REPAIR IN SWINE SKIN USING HEALING GEL COMPOSED OF GREEN PROPOLIS, ANDROGRAPHOLIDE AND 

BAICALIN

KEY WORDS:

Wounds, Porcine model, Chronic wounds, Healing

PAGES: 99
BIG AREA: Ciências Agrárias
AREA: Medicina Veterinária
SUBÁREA: Clínica e Cirurgia Animal
SPECIALTY: Clínica Cirúrgica Animal
SUMMARY:

Skin injuries cause the dissolution of the body's protective barrier and several aggressive factors such as diabetes, 

contamination, neuropathies and vascular pathologies can cause difficulties in the spontaneous closure of wounds.

Due to these difficulties, the correct management of the wound is essential so that we can accelerate healing and 

avoid chronicity. New studies are developed with phytotherapeutic actives for biofilm control and closure 

acceleration. The combination of Propolis, Andrographolide and Baicalin assets were tested separately and proved 

to be efficient in bacterial control and healing associated with low cytotoxicity. In the present study, hydrogels 

formulated with the actives were compared with commercial positive and saline negative controls. The excisional 

model of healing in pigs was used due to the physiological similarity of the skin with humans. Two castrated and 

dewormed male pigs weighing 40 kg were used to make the wounds on the back. Dressings and assessment of 

wounds were performed daily. Wounds were photographed with a template every seven days and histological 

samples were collected on E1 on D14 and D28 and on E2 on D21. The wounds treated with hydrogels closed 

effectively and, in the histological analysis, showed better collagen deposition and epithelialization than the 

others, but further studies must be conducted to confirm their effectiveness.

BANKING MEMBERS:
Presidente - 1765666 - FABIO HENRIQUE BEZERRA XIMENES
Interna - 1352451 - SIMONE PERECMANIS
Externa à Instituição - PATRÍCIA FURTADO MALARD