Protocol for the assessment of electrical and vocal biomarkers as predictors of cognitive performance in adults and the elderly
screening test, EEG, speech, cognitive rehabilitation
The extension of human life expectancy, coupled with the evolution of sciences such as neuroscience, demands better approaches for quality longevity. **Objective**: To develop a protocol that will be used for a longitudinal clinical trial that will analyze the possibility of proving simpler biomarkers of cognitive performance that are easy to apply by health professionals. This is a prospective experimental cohort study aimed at developing the analysis protocol for two possible biomarkers, the electroencephalogram and the analysis of speech fluency, associating them with the participant's cognitive performance in the standardized cognitive screening test Montreal Cognitive Assessment (MOCA). Furthermore, during an application of cognitive rehabilitation training analyzing the electrical behavior of the cerebral cortex measured through electroencephalogram (EEG) and the analysis of speech fluency using algorithms, both associating the findings of the analyses with healthy brains to those with impairments. In this way, all analyzed biomarkers will be confronted with the results of cognitive screening tests, which are initial instruments used to investigate degenerative processes. **Materials and Methods**: Selection of participants aged 50, with healthy aging or mild cognitive impairment or early dementia (CDR between 0 and 1), considering age, education, and occupational status. The materials used will be: screening tests, self-report questionnaires, cognitive rehabilitation technique, the electroencephalogram, voice analysis programming. The analysis of the groups will be carried out by non-parametric statistical mapping. **Results**: The results of the pilot plan will refine the application of research collection, with performance analysis data between the electroencephalogram and the screening test