Banca de DEFESA: Jéssica Nayane Gomes de Souza

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Jéssica Nayane Gomes de Souza
DATE: 29/08/2022
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

DRD3 GENE IN PATIENTS WITH PAPILLARY THYROID CARCINOMA

KEY WORDS:

POLIMORFISMO GENÉTICO DO GENE DRD3 EM PACIENTES COM CARCINOMA PAPILÍFERO DA TIREOIDE

PAGES: 100
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

To identify whether the dopamine D3 receptor (DRD3) Ser9Gly
(rs6280) polymorphism affects susceptibility to papillary thyroid carcinoma
(PTC) and/or its prognosis. Methods: This descriptive observational case-
control study with patients with PTC who underwent thyroidectomy and sodium
iodide (131I) radiopharmaceutical treatment and unrelated healthy volunteers.
DRD3 SNP Ser9Gly (rs6280) genotyping was performed by PCR-RFLP, and
results were observed, compiled and analyzed using SPSS version 28.0.
Results: The genotype frequencies of the healthy volunteers were in Hardy-
Weinberg equilibrium. No statistical difference was found between the
genotypes and allele frequencies between the PTC and control groups,
although the PTC group had proportionally fewer ancestral S alleles compared
with polymorphic G. Similarly, there was no association between the
polymorphism and the clinical characteristics of PTC patients. Conclusion: The
DRD3 Ser9Gly polymorphism (rs6280) was not associated with PTC
susceptibility in the Brazilian population studied, nor with other PTC
characteristics and prognoses. Further studies should be conducted in other

populations with different genetic makeup to help understand the possible
effects.

BANKING MEMBERS:
Presidente - 2495888 - IZABEL CRISTINA RODRIGUES DA SILVA
Interna - 1697332 - DANIELA CASTILHO ORSI
Externo à Instituição - BRUNO ROGERIO DE SOUZA
Externo à Instituição - GREICE MARIA RODRIGUES DE SOUZA LUCENA