Banca de QUALIFICAÇÃO: Max Sarmet Moreira Smiderle Mello

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : Max Sarmet Moreira Smiderle Mello
DATE: 14/12/2022
TIME: 08:00
LOCAL: on line (Teams)
TITLE:

An exploratory study on the chewing and swallowing physiology of old healthy
marmosets (Callithrix jacchus) by cineradiographic imaging

KEY WORDS:

Callithrix, cineradiography, mastication, swallowing, healthy aging, animal model

PAGES: 62
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

BACKGROUND: Non-human primates are the closest animal models to humans
regarding genetics, physiology, and behavior. Marmoset monkeys in particular are one of the most versatile species for biomedical research. In human research, the separation of the effects of age from other clinical issues is difficult because of a number of environmental factors that affect the neurobiology of human aging. Therefore, the marmoset can be used as a model to explore the changes in the masticatory and swallowing physiology during healthy aging. OBJECTIVES: To assess the changes in the masticatory and swallowing physiology during the healthy aging of marmosets using cineradiographic imaging. Additionally, we aimed to describe anatomic characteristics during the aging process, test the marmoset as a model for masticatory and swallowing studies, and assess the feasibility of the cineradiography method for this type of study.

METHODS: 21 healthy captivity marmosets (0-19 years old) were assessed regarding masticatory and swallowing functions by cineradiography. For the experimental procedure, we used a micro focal X-ray
source apparatus and a beryllium fast-response image intensifier. Image post-processing was done using ImageJ, VLC, and Kinovea software. RESULTS: Through 53 observations we found several differences in the masticatory and swallowing physiology among the age groups, both anatomical, functional, and behavioral. The older animals tended to eat larger portions at a time, eating faster and performing fewer
mastications and swallows in comparison with the younger marmosets. Esophageal stasis was present in almost all individuals. CONCLUSIONS: Through experiments using cineradiography we found several differences in the masticatory and swallowing physiology between different age groups in healthy marmosets
from infancy to the super-old stage of life. We consider the marmoset an excellent model for masticatory and swallowing studies and cineradiography has proven to be a suitable method for masticatory and swallowing studies. In general, our findings support that the changes observed between the age groups seem to be part of the natural aging process of marmosets, similar to the aging process observed in humans.

BANKING MEMBERS:
Externa à Instituição - MARISTELA SAYURI INOUE-ARAI
Externo à Instituição - DANILO SIMONINI TEIXEIRA - UESC-BA
Presidente - 1646309 - JORGE LUIS LOPES ZEREDO
Externo ao Programa - 2376346 - OTAVIO DE TOLEDO NOBREGA