''CONSTRUCTING AN AGENDA OF COVID-19 RESEARCH PRIORITIES IN BRAZIL''
Research priorities; Health research agenda; Research and development; Covid-19; Brazil
Emerging and reemerging infectious diseases are an ongoing challenge for global world health. In 2019, cases of pneumonia of unknown origin reported in Wuhan, China, led to the discovery of a new type of Coronavirus (2019-nCoV). The Covid-19 pandemic resulted in unprecedented challenges for health services and systems worldwide. Although science, technology and innovation (ST&I) played a key role in coping with the disease, knowledge gaps remain. The aim of this study was to propose an agenda of Covid-19 research priorities.
Methods: This was a qualitative study performed in two stages. The first was a broad-based consultation to identify research priorities cited by researchers, health, science and technology administrators, healthcare professionals and health system users via an electronic questionnaire. These priorities were organized according to the four categories of the COVID-END initiative (COVID-19 Evidence Network to support Decision-making): I. Public health measures, II. Clinical management, III. Health system arrangements, and IV. Economic and social responses. In the second stage, the proposed priorities were submitted to two rounds of analysis by a panel of Covid-19 experts using the Delphi method on a Likert scale, with a view to achieving consensus. Results: There were 71 participants in the first stage and 20 in the second, with 186 responses received in the broadbased consultation, consolidated into 161 priority lines of Covid-19 research. Of these, 139 achieved consensus in the first round of the Delphi method, with another 41 lines proposed and included for assessment in round two, resulting in 179 Covid-19 research lines. Issues related to the assessment, impact and sequelae of Covid-19 and long Covid predominated, particularly mental diseases and immunodepression. The population that attracted the most interest among participants was children. Conclusions: This study contributes by proposing an agenda of Covid-19 research priorities aimed at strengthening science and technology and guiding the allocation of investments by government institutions and research support agencies in Brazil.