Banca de QUALIFICAÇÃO: Robson Fernando Borges

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : Robson Fernando Borges
DATE: 12/08/2024
TIME: 09:00
LOCAL: FCE: Laboratório de Fisiologia Clínica do Exercício (UAC)
TITLE:

Cardiorespiratory behavior and peripheral and respiratory muscle oxygenation in post-acute covid-19 syndrome: influence of sex and severity of the acute phase of covid.

KEY WORDS:

Exercise Test; Tissue Oxygenation Index; Covid-19; Post-Acute COVID-19 Syndrome.

PAGES: 42
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Post-Acute COVID-19 Syndrome (PASC), as known as Long COVID, manifests as persistent symptoms adversely impacting individuals' quality of life and physical capacity. Severe COVID-19 infection primarily targets the respiratory system, leading to acute respiratory distress syndrome. Research suggests that persistent functional limitations post-COVID-19 infection may stem from respiratory impairments, supported by findings of respiratory limitations in spirometry tests. Cardiopulmonary exercise testing (CPET) has emerged as a valuable tool in assessing exercise limitations, revealing lower peak VO2 and increased symptomatology in post-COVID-19 individuals. Exercise intolerance in these patients may also be attributed to peripheral muscle fatigue, with studies indicating a less influential role of pulmonary and cardiovascular systems. However, the specific mechanisms underlying exercise intolerance in post-COVID-19 patients remain incompletely understood. A retrospective observational study was conducted from June 2020 to August 2021. Subjects were individuals referred for evaluation, aged over 18, with a history of symptomatic COVID-19 and without prior cardiovascular or pulmonary diseases. Cardiopulmonary exercise testing (CPET) was performed using a standardized protocol, assessing various physiological parameters including ventilatory efficiency, metabolic demand, and oxygen consumption. Near-infrared spectroscopy (NIRS) was utilized to evaluate oxygenation activity in respiratory and peripheral muscles during exercise. Respiratory musculature analysis revealed significant changes in tissue saturation index (TSI%), deoxygenated hemoglobin (HHb), and hemoglobin difference (HbDiff), particularly in men with critical illness. Peripheral musculature analysis indicated significant differences in HHb levels in the vastus lateralis muscle, with implications for oxygen extraction and blood flow regulation. Cardiopulmonary test analysis demonstrated significant differences in ventilatory efficiency, metabolic demand, and oxygen consumption per kilogram across sexes and severity, highlighting exercise intolerance in post-COVID-19 patients. Alterations in respiratory and peripheral musculature responses during exercise were observed, particularly in individuals with critical illness. Respiratory muscle recruitment and metabolic activity played pivotal roles in influencing TSI% measurements, while differential profiles of oxygen extraction and blood flow were noted in peripheral muscles. Cardiopulmonary responses differed across sexes and severity, with implications for gas exchange efficiency and oxygen utilization. The study elucidates the complex interplay between respiratory and peripheral musculature responses during exercise in post-COVID-19 syndrome.

COMMITTEE MEMBERS:
Presidente - 1657320 - GERSON CIPRIANO JUNIOR
Externo à Instituição - PAULO EUGENIO OLIVEIRA DE SOUZA E SILVA - SES-DF
Externo ao Programa - 1772302 - SERGIO RICARDO MENEZES MATEUS - null