Banca de DEFESA: FELIPE SOUSA SIQUEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : FELIPE SOUSA SIQUEIRA
DATE: 19/07/2023
TIME: 09:30
LOCAL: Plataforma Teams
TITLE:

Nanometric Scale Hydrophilic Reticulated Polymer Network As A Nanotechnology Drug-Release System

KEY WORDS:

Tauopathies; Polymers; Polyelectrolytes; Acetylcholine; Drug Liberation

PAGES: 60
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Neurodegenerative diseases are a group of diseases that are identified by the deterioration of the central nervous system and may manifest in varying ways based on the location or neural groups affected. Within this array of ailments, there exists a distinct category known as tauopathies, which pertains to neurodegenerative disorders resulting from the accumulation of a protein known as tau. The aim of this study is to present the process of synthesis and characterization of a nanotechnology system that is composed of the connection of two inert polymers called chitosan and gellan gum. These polymers are associated with gallocyanine, a dye commonly employed for Nissl bodies, which forms a complex with acetylcholine and has recently been discovered to be capable of binding to LRP5 and LRP6 receptors and inhibiting their interaction with a protein called DKK1 to inhibit tau protein phosphorylation. As a result, we measure the particles size in water, their zeta potential, Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, and release profiles by UV/visible spectroscopy. Consequently, the outcomes obtained indicated that the produced system exhibits a diameter ranging from 10 to 100 nm in its dry state, with an average diameter of 500 nm swollen in solution, lacks an electrostatic charge, exhibits an isoelectric point, and has a superior continuous release to pH 7.4. Thus, it demonstrates the fundamental characteristics of a promising system for treatment and presents results that align with those described in the literature.

COMMITTEE MEMBERS:
Externa ao Programa - 1974898 - CAMILA ALVES AREDA - nullPresidente - 1644041 - CLAURE NAIN LUNARDI GOMES
Interno - 1652361 - MARCELO HENRIQUE SOUSA
Externo à Instituição - ODAIR ANTONIO BARBIZAN - IFRO