Banca de DEFESA: LIGIA CANONGIA DE ABREU CARDOSO DUARTE

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LIGIA CANONGIA DE ABREU CARDOSO DUARTE
DATE: 25/09/2023
TIME: 15:00
LOCAL: FCE- UEP
TITLE:

Influence of changes in molecular patterns on the prognosis of patients with thyroid cancer submitted to doses of the radiopharmaceutical sodium iodide (131I).

KEY WORDS:

papillary thyroid carcinoma, genetic polymorphism, BAX -248 G>A, BCL2 GCC>ACC (Ala43Thr), IL12B +1188 A>C e MAOA uVNTR.

PAGES: 113
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Thyroid gland carcinoma accounts for approximately 1% of all carcinomas, however, it is the most prevalent endocrine neoplasm in the world; and follicular thyroid carcinoma accounts for between 10 to 25% of malignant tumors of this gland, depending on the population studied. Papillary thyroid carcinoma (PTC) is the most common subtype and has the best overall prognosis, with metastases most commonly involving the cervical lymph nodes and, less commonly, the lungs. Among the various molecular markers described are genetic variants that can be understood as the presence of molecular change in at least 1% of the population, known as polymorphism. Molecular markers of thyroid cancer are found in more than 70% of differentiated carcinomas and the understanding of their different molecular mechanisms is favorable to new perspectives for their diagnosis and treatment. The aim of the present study is to determine the prevalence of genetic polymorphisms BAX -248 G>A, BCL2 GCC>ACC (Ala43Thr), IL12B +1188 A>C, MAOA uVNTR, IL 13 +2044 G>A Arg110Gln, IL 4 VNTR, IL 5 -703 C>T, and to measure the concentration of serum proteins in patients with thyroid cancer who underwent treatment with the Radiopharmaceutical Sodium Iodide (131I) and compare with the healthy group in the follow-up, treatment, prognosis and disease staging, in a prospective and case-control study. To date, genotypic analysis was performed, using amplification and enzymatic restriction techniques, of the following genes: BAX -248 G>A, BCL2 GCC>ACC (Ala43Thr), IL12B +1188 A>C e MAOA uVNTR. This study is a pioneer in the analysis of such polymorphisms associated with CPT in a sample from the Federal District, Brazil. The study concluded that regarding the presence of the G allele in the BAX gene polymorphism (-248 G>A) and the occurrence of thyroid cancer, the G allele is more common between the groups (p=0.009) and, when analyzing the In dichotomized genotypes, the GG genotype is a protective factor for the occurrence of Papillary Thyroid Carcinoma (p=0.012; OR= 0.313; CI=0.123-0.794). The MAOA uVNTR polymorphism showed statistical difference between sex and the different types of genotype (p=0.029) demonstrating that there is a protection for women having the LL genotype (OR=0.17; CI=0.03-0.89), analyzing the same polymorphism and associating TNM staging with patients diagnosed with CPT, a statistically significant difference was observed between patients with stage T1+T2 who carried the LL genotype and those who carried the LS+SS genotype (p=0.015).

COMMITTEE MEMBERS:
Interna - 1697332 - DANIELA CASTILHO ORSI
Presidente - 1764941 - DIEGO MADUREIRA DE OLIVEIRA
Externo ao Programa - 2122537 - MARCELO DE MACEDO BRIGIDO - nullExterno à Instituição - MARCIANO REGIS RUBINI - EMBRAPA
Externa à Instituição - VIVIAN TAÍS FERNANDES CIPRIANO - UDF