Assessment of sarcopenia behavior, lung function, respiratory muscle strength and quality in individuals with chronic kidney disease undergoing hemodialysis treatment: a longitudinal study
Sarcopenia, Hemodialysis, Respiratory function tests, Respiratory muscles, Ultrasound
Context: In patients with chronic kidney disease (CKD), sarcopenia promotes a decline in functionality, greater frequency and length of hospitalization, reduced quality of life, greater susceptibility to infections, falls and mortality. In patients with CKD undergoing dialysis treatment, fluid overload can lead to hyperventilation due to compromised lung compliance, electrolyte imbalance and consequent reduction in oxygen diffusion, promoting an increase in demand on the respiratory muscles, favoring respiratory muscle weakness. However, scientific evidence on the prevalence of sarcopenia and its relationship with lung function and respiratory muscle strength in this population is still scarce. Objective: To evaluate the behavior of sarcopenia, lung function, respiratory muscle strength and quality in individuals with chronic kidney disease undergoing hemodialysis treatment. Methods: This is a longitudinal, prospective study that will be developed in two phases. Each phase will consist of two evaluation stages. The first stage will be carried out at the Nephrology Unit of the State Department of Health of the Federal District of the Taguatinga Regional Hospital (HRT), where participants will undergo analysis of sociodemographic and clinical data, bioimpedance, laboratory tests, anthropometry, calf circumference, test of physical performance, handgrip muscle strength and SARC-CalF questionnaire. The second stage will take place at the Clinical Exercise Physiology Laboratory of the Faculty of Ceilândia (LabFCE) of the University of Brasília, where participants will carry out assessments of body composition by dual-energy x-ray absorptiometry, muscle ultrasound analysis of the diaphragm, function pulmonary and inspiratory muscle strength. Assessments will be carried out during the week of hemodialysis treatment, in the second and third session, and reassessments will take place after 3 months.