Banca de DEFESA: BRUNA RODRIGUES GONTIJO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BRUNA RODRIGUES GONTIJO
DATE: 31/07/2023
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

INFLUENCE OF GENETIC POLYMORPHISMS 3'UTR SLC6A3 VNTR AND NOS3 INTRON 4 VNTR IN MAJOR DEPRESSIVE DISORDER

KEY WORDS:

SLC6A3; Endothelial Nitric Oxide Synthase; Genetic Polymorphism; Major Depressive Disorder

PAGES: 165
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Major Depressive Disorder is a disabling condition that interferes with the individual's cognition and psychosocial functioning, with a higher incidence in females than in males. Among the symptoms are sadness, hopelessness, exhaustion, depressed mood, anhedonia and behavioral changes. The development of the disease has a multifactorial character in which there is the involvement of social, cultural, biological and genetic parameters. Thus, the present study aimed to verify the influence of the genetic variant 3'UTR SLC6A3 VNTR in different populations with MDD, through a systematic review, in addition to identifying and analyzing the polymorphism in intron 4 of the NOS3 gene, in patients with MDD undergoing treatment for at least 3 months at CAPS III in Samambaia Sul - DF. For the development of the systematic review, a search for articles was carried out in the databases: Pubmed, Web of Science, Virtual Health Library (BVS) and Scopus and, through selection by pre-established inclusion and exclusion criteria, 6 studies were chosen. In the case of the cross-sectional, descriptive and case-control study, in which blood samples were collected from a control group and a case group. These samples were submitted to the laboratory technique of Polymerase Chain Reaction (PCR) for their genotyping. A significance level of 5% was adopted. Regarding the results found, in the systematic review of the SLC6A3 (DAT1) 3'UTR VNTR gene, an association was demonstrated between the SS (9R/9R) genotype and the presence of the S (9R) allele with the risk of developing TDM, in addition to influence the decrease in response to antidepressant therapy. In addition, in the case-control study regarding the NOS3 INTRON 4 VNTR gene, it was observed that there was a statistically significant difference in the genotype distribution between individuals with MDD and healthy individuals, and the presence of the b/b genotype is a protective factor for the development of the disease. There was also a correlation between the b/b genotype with high cholesterol and the a/a and a/b genotype with high glucose in patients who had MDD. Therefore, as it is a multifactorial disease, it is increasingly essential to establish new studies of genetic polymorphisms in order to improve the diagnosis, treatment and quality of life of patients.

COMMITTEE MEMBERS:
Externo à Instituição - BRUNO ROGERIO DE SOUZA - IFB
Interna - 1697332 - DANIELA CASTILHO ORSI
Presidente - 2495888 - IZABEL CRISTINA RODRIGUES DA SILVA
Externo à Instituição - MARCIANO REGIS RUBINI - EMBRAPA