Banca de DEFESA: Luciana Bartolomei Orru D'Avila

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Luciana Bartolomei Orru D'Avila
DATE: 21/08/2023
TIME: 14:00
LOCAL: UNB-FCE
TITLE:

LONGITUDINAL STRAIN AND MYOCARDIAL WORK IN SYMPTOMATIC PATIENTS HAVING RECOVERED FROM COVID-19 AND POSSIBLE ASSOCIATIONS WITH THE SEVERITY OF THE DISEASE.

KEY WORDS:

Pós-Acute COVID-19 Syndrome; Echocardiography; Global Longitudinal Strain; Myocardial Work; Cardiorespiratory Fitness

PAGES: 67
BIG AREA: Outra
AREA: Multidisciplinar
SUMMARY:

Background: COVID-19 may have residual consequences in multiple organs, including the cardiovascular system. Persistent symptoms are frequent, and little is known about the longterm cardiovascular consequences. The aim of present investigation is to quantifymyocardial function in symptomatic individuals with previous COVID-19 and investigate the association between illness severity and myocardial function. Methods: Retrospective cross section study in which symptomatic individuals with previous moderate to critical COVID-19 underwent echocardiographic analysis of left ventricle global longitudinal strain (LVGLS) and myocardial work (MW) between June 2021 and August 2022 from the rehabilitation programme at a public university in Midwest Brazil. Individuals also performed cardiopulmonary testing (CPX) to assess peak oxygen uptake (VO2peak).Differences between illness severity subgroups (critical versus moderate/severe) were analyzed by Mann-Whitney test. Correlations were calculated using the Spearman correlation test. Multilinear regressions were performed to evaluate the influences of COVID-19 severity, body mass index, age, and sex on MW. Results: Sixty-six patients were screened for the study and fifty-six individuals were included (critical subgroup: 17; moderate/severe subgroup: 39), 59% females; median age: 56 years (IQR: 43-63). CPX revealed a substantial reduction in VO2peak (median of 53% of predicted values). LVGLS were not statistically different between subgroups. Global wasted work (GWW) was higher in the critical subgroup [146 (104-212) versus 121 (74-163) mmHg %, p = 0.01] and global work efficiency (GWE) was lower in this subgroup [93 (91-95) versus 94 (93-96), p = 0.03]. Illness severity was the only independent predictor of GWW and GWE (GWW: r2 = 0.167; p = 0.009; GWE: r2 = 0.172; p = 0.005) in multilinear regressions. Conclusions: In our study with long COVID-19 individuals, despite having a similar LVGLS, patients had subclinical LV dysfunction, demonstrated only by an increase in GWW and a decrease in GWE.

COMMITTEE MEMBERS:
Presidente - 1657320 - GERSON CIPRIANO JUNIOR
Externa à Instituição - JOÃO CESAR NUNES SBANO - USP
Externo à Instituição - Sergio Henrique Rodolpho Ramalho - CEPT
Interna - 1191281 - VERA REGINA FERNANDES DA SILVA MARAES