CLINICAL SERVICES PROVIDED BY PHARMACISTS IN HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) IN A PEDIATRIC HOSPITAL IN THE FEDERAL DISTRICT: A STRUCTURING PROPOSAL
Hematopoietic Stem Cell Transplantation; Bone Marrow Transplantation; Pharmaceutical Care; Quality of Healthcare; Implementation Science
Introduction: The Hematopoietic Cell Transplant (HCT) is a highly complex procedure and requires extensive patient care, including pharmaceutical care services, to support the effectiveness and safety of the treatment. Objective: To develop the proposition of a pharmaceutical care service in the hematopoietic cell transplant (HCT) sector of a pediatric hospital in Distrito Federal, Brazil. Methods: This is a multi-method study divided into four steps. Steps 1 and 2 included the data analysis from the national scenario, regarding both to hematopoietic cell transplantation centers and to pharmaceutical care services in HCT. These steps consisted in document analysis, questionnaire application and semi-structured interviews. In Step 3, the local scenario was examined regarding the perception and necessities for the pharmaceutical care service at the HCT sector of the pediatric proponent hospital, a focus group and a semi-structured interview were used. Finally, in Step 4, the proposal for a pharmaceutical care service at the HCT sector of the hospital under study was made. Results: There were 82 HCT centers and 3991 transplant (autologous and allogeneic) procedures were performed during the year 2022, according to the Brazilian Association of Organ Transplantation (ABTO). The Southeast and South regions of Brazil stood out with the highest number of transplant centers and HCT performed in 2022, on the other hand, the North region of Brazil had the lowest results. The pharmaceutical care services are mainly developed on an outpatient and inpatient basis, focusing on: medication reconciliation, pharmacotherapeutic monitoring, review of pharmacotherapy, participation in multidisciplinary meetings, discharge guidance and outpatient consultation. The proposal for structuring the service highlights the recommendation of pharmacists working across the entire line of HCT care, from pre-HCT to post-HCT (D+100). Furthermore, the interviewees' speeches highlighted the need for process indicators, therefore, to improve the service the inclusion of result indicators (clinical, economic and humanistic) is suggested. Conclusion: It was possible to identify strategic points for the construction of the pharmaceutical care service in the HCT sector of the proponent pediatric hospital, considering structural, human and logistical aspects, processes and results, intending to promote effectiveness and safety during the usage of the complex medication adopted in all phases of HCT, furthermore the qualification of the care provided and the strategies for monitoring/evaluating the service