Banca de QUALIFICAÇÃO: Filipe Balbino da Costa Lohmann

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : Filipe Balbino da Costa Lohmann
DATE: 31/01/2023
TIME: 14:00
LOCAL: FCE/ Microsoft Teams
TITLE:

Proteomic Profile of the Gastrocnemius Muscle following Achilles tendon injury

KEY WORDS:

Achilles Tendon Injury, Extracelullar Matrix, Muscle Remodeling, Proteomics

PAGES: 20
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Although immobilization is a factor that has deleterious consequences on skeletal muscle, a pertinent and still scarce issue in the literature refers to the muscle reaction when affected by an injury to the adjacent tendon. Objective: The aim of this study will be to evaluate the effects of partial injury to the Achilles tendon (CT) on the trophism and plasticity of the gastrocnemius (MG) muscle after 3,14,28 and 55 days of partial rupture. Methods: The protein profile of MG will be evaluated through proteomics assays being analyzed using the Nano-LC-MS/MS protocol. The most relevant proteins detected by proteomics will be confirmed using WB. Expected results: It is expected that MG presents a change in the profile of proteins that signal muscle synthesis and degradation, as well as changes in proteins responsible for the support and maintenance of ECM, showing apoptotic and inflammatory processes due to partial CT injury. Proteomics assays are expected to reveal proteins that allow for an understanding of muscle metabolic functioning after CT injury.

BANKING MEMBERS:
Externa à Instituição - RAQUEL AGNELLI MESQUITA - UNINOVE
Externo à Instituição - BERNARDO PETRIZ DE ASSIS - UDF
Interna - 1932929 - GRAZIELLA FRANCA BERNARDELLI CIPRIANO
Presidente - 1962055 - RITA DE CASSIA MARQUETI DURIGAN