Banca de DEFESA: Victoria Lyssa Assis de Mendonça

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Victoria Lyssa Assis de Mendonça
DATE: 18/12/2023
TIME: 14:30
LOCAL: on line
TITLE:

ADAPTIVE RESPONSES OF SKELETAL MUSCLE TO CALCANEAL TENDON AFTER PARTIAL INJURY: INSIGHTS INTO REMODELING AND PLASTICITY

KEY WORDS:

skeletal muscle remodeling, gene expression, intracellular signaling, tendon lesion

PAGES: 28
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Skeletal muscle is a highly adaptive tissue, capable of responding to different physiological and functional demands, even in situations that may cause instability. Objectives: Therefore, the objective of this study is to evaluate the effects of partial injury to the calcaneal tendon (CT) in the remodeling and plasticity of the gastrocnemius muscle at times. Methods: The study was carried out with Wistar mice randomly divided into five groups. The control group consists of animals that are not subjected to partial calcaneal tendon damage and another four groups that are subjected to partial calcaneal tendon damage and subdivided by the time of dyeing: 3, 14, 28 and 55 days after injury. The gastrocnemius muscle was collected and used for gene expression analysis, flow cytometry and morphology. The calcaneal tendon was analyzed only to verify the presence of the partial injury. Results: The partial injury of the CT caused major alterations in the homeostasis of the gastrocnemius when compared to genetic expression in the 3 days group compared to the rest, especially in the control group. For the cytokine panel and morphological analyses, the main alterations occurred in the group 55 days when compared to the other groups. Conclusion: The results of this study suggest that partial injury can negatively affect the pathways of intracelular signaling and degradation, disturbing the regulatory mechanisms of the muscular extracellular matrix and communication with the tendon. However, skeletal muscle seems to mitigate these harmful effects in comparison with lesions that affect muscle and tendon.

COMMITTEE MEMBERS:
Externo à Instituição - THIAGO DOS SANTOS ROSA
Interno - 1952930 - FELIPE AUGUSTO DOS SANTOS MENDES
Externo à Instituição - JEESER ALVES DE ALMEIDA - UFMS
Presidente - 1772842 - PATRICIA AZEVEDO GARCIA