Banca de DEFESA: Maria Camila Acero Castillo

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : Maria Camila Acero Castillo
DATE: 29/07/2022
TIME: 16:00
LOCAL: A definir
TITLE:

BIBLIOGRAPHIC REVIEW ON THE PHARMACOLOGICAL PROPERTIES OF KETAMINE IN SCHIZOPHRENIA AND DEPRESSION"

KEY WORDS:

ketamine; NMDA; schizophrenia; depression

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Ketamine is an NMDA (N-methyl-D-aspartate) glutamate receptor antagonist, which has a myriad of pharmacological and behavioral effects, including anesthetic, sedative, amnestic, analgesic, and anti-inflammatory properties. However, at subanesthetic doses, numerous studies over several decades have established a relevant profile of ketamine in both the study of schizophrenia and the treatment of depression. In this review of the scientific literature, an overview of the state-of-the-art role of ketamine as a pharmacological model of schizophrenia and as an antidepressant drug both in animal models and in studies with human participants is discussed. The action of this compound for the induction of positive, negative, and cognitive symptoms helped to shape and consolidate the glutamatergic hypothesis of schizophrenia. On the other hand, there are very promising the clinical and preclinical results of ketamine in the treatment of refractory. When exploring the mechanisms of action of this compound, in both psychiatric disorders, especially through the involvement of NMDA receptors, a mutual contribution between research lines in Psychopharmacology is evidenced.

BANKING MEMBERS:
Externa à Instituição - SILVIA BOTELHO DE OLIVEIRA
Externo ao Programa - 2354637 - FABIO VIEGAS CAIXETA
Presidente - 1952915 - RAFAEL PLAKOUDI SOUTO MAIOR
Externo ao Programa - 1161674 - VITOR AUGUSTO MOTTA MOREIRA