Banca de DEFESA: Maria Clara Barreiros da Costa Ribeiro

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Maria Clara Barreiros da Costa Ribeiro
DATE: 10/10/2022
TIME: 14:00
LOCAL: Auditório do Laboratório Interdisciplinar de Biociências - FM/UnB
TITLE:

O Benefício do Uso de Probióticos em Giardíase

KEY WORDS:

Probiotics, giardiasis, Giardia lamblia, Giardia intestinales, in vivo, murine

PAGES: 1000
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

“CONTEXT: Probiotics are live microorganisms of different species that can confer a benefit when ingested in a certain amount. Over the years, studies involving probiotics have developed to expand their use in areas such as disorders and allergies. On the other hand, studies in other areas of application are still needed so that probiotics can be used as an alternative intervention. As an example of this, there is an important question regarding giardiasis caused by protozoa of the genus Giardia. This disease afflicts populations around the world and sometimes alternatives that do not affect patients are necessary. Studies with probiotics have the potential for an alternative treatment of patients with parasitic diseases since their use promotes the balance of the intestinal flora, competing with the parasites and thus improving the condition of patients. However, most of the works that analyze this potential with probiotics are carried out in vitro or in vivo in Murine organisms. There are still few studies that analyze the effects of probiotics in humans affected with intestinal parasites. OBJECTIVE: To evaluate the use of probiotics as an alternative intervention for giardiasis in in vivo studies carried out with murines and whether it is possible to start human trials from that moment. METHOD: In this Systematic Review, eligibility criteria for inclusion of studies in the review were defined. Papers dealing with intestinal parasitic diseases were included, intervention studies with probiotics and in vivo studies with mice. Works that dealt with non-parasitic intestinal diseases were excluded; that do not use probiotics; who have co-intervention in the same group in their methodology; review studies and works that were not complete. The systematic review was registered in PROSPERO – International Prospective Register of Systematic Review. A definitive search was made in the databases on 02/17/2020 through a search strategy made with keywords found using the Mesh program in Embase databases; Lilacs; Livivo; Pubmed; Scopus; Web of Science and Gray Literature (Google Scholar; OpenGrey and ProQuest. EndNote web software, Rayyan QCRI were then used to assist in the management, removal of duplicates and selection of studies. To analyze the risk of bias for each study, the SYCLE checklist was used. The entire selection process was carried out by two reviewers (1R and 2R) independently and the third reviewer (3R) to break the tie when there is a disagreement between the first reviewers. Data from each article included in the selection steps were then collected by Reviewers 1 and 2 (1R and 2R) and these data were organized in a table to analyze the results found and the risk of bias in these studies.

BANKING MEMBERS:
Externa à Instituição - Cristiane Jeyce Gomes Lima - SESDF
Presidente - 1278451 - ELIETE NEVES DA SILVA GUERRA
Interno - 2189235 - LUIZ CLAUDIO GONCALVES DE CASTRO
Externa ao Programa - 2489028 - RENATA PUPPIN ZANDONADI MAGALHAES