Banca de DEFESA: Letícia Lopes Quirino Pantoja

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : Letícia Lopes Quirino Pantoja
DATE: 25/11/2022
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

Radiographic evaluation of the temporomandibular joint and oral health-related quality of life in patients with Osteogenesis Imperfecta

KEY WORDS:

Osteogenesis Imperfecta, Temporomandibular Joint, Temporomandibular Joint, Pamidronate, Health Related Quality Of Life

PAGES: 1000
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Some systemic pathological conditions such as skeletal dysplasias can lead to craniofacial alterations and are potential risk factor for temporomandibular joint development (TMJ) and masticatory system functioning. Osteogenesis imperfecta (OI) is a skeletal dysplasia and is considered a group of rare genetic disorders characterized by different degrees of bone fragility and increased susceptibility to fractures. bone and deformity. Extra-skeletal manifestations such as ligament laxity, muscle hypotonia, malocclusion and dentinogenesis imperfecta are frequently observed and can affect the craniofacial complex. Although many OI patients present orofacial manifestations, disruption involving the TMJ and their possible functional consequences, as well as their impact on emotional and behavioral aspects, are poorly reported in the literature. This study had two objectives: (1) to evaluate the influence of OI and its treatment on TMJ development through the characterization of the trabecular bone in the mandibular condyle; (2) to assess the impact of orofacial alterations and OI severity on the Oral Health-related Quality of Life index (OHRQoL) of patients. For the first objective, fractal dimension (FD) analysis of the condyle region was performed on panoramic radiographs of 33 patients (2-17 years old) treated with disodium pamidronate and compared with a control group of 99 individuals without OI. Effect of cumulative pamidronate dose, duration of treatment, and age at treatment onset on FD outcomes were evaluated using a linear regression model with mixed effects. For the second objective, the Brazilian version of the Child Perception Questionnaire (CPQ) was applied to children and adolescents grouped by age (8- 10 and 11- 14 years old). The relationship between the OHRQoL index and its health domains, OI types of and the presence of orofacial manifestations was evaluated. FD in patients was significantly lower compared to healthy adolescents (p < 0.01). The mean FD in the study group was 1.23 (± 0.15), and 1.29 (± 0.11) among controls. There was no statistically significant difference in this result regardless of sex. The type of OI, age at treatment onset and duration of therapy were variables that had a statistically significant effect on FD. The OHRQoL index for patients between 8 and 14 years old was 6.89 ± 6.59. It was lower among OI type III patients (5.9 ± 5.47) than in type IV patients (6.88 ± 5.47). 8.77). The index was lower for children (6.59 ± 7.06) than for adolescents (7.4 ± 6.04). This study demonstrated that the bone architecture of the condyle may be altered in pediatric patients with moderate and severe forms of OI. Furthermore, pamidronate treatment seems to affect this natural history, making the trabecular bone structure of the condyle more complex. It also demonstrated that HoRQoL was similar in patients with moderate and severe OI. The oral symptoms domain is the most relevant for the index among patients aged 8 to 14 years. The perception of HRQoL among adolescents was worse than among children.

BANKING MEMBERS:
Presidente - 2295825 - ANA CAROLINA ACEVEDO POPPE
Externa ao Programa - 1122542 - LILIAN MARLY DE PAULA
Externa à Instituição - Fabiana Tolentino de Almeida - UniAlberta
Externa à Instituição - HELIANA DANTAS MESTRINHO - UnB
Externo à Instituição - PAULO MARCIO YAMAGUTI - HUB