Banca de DEFESA: KELLY CRISTINA SAAD SIMPLICIO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : KELLY CRISTINA SAAD SIMPLICIO
DATE: 06/12/2022
TIME: 08:00
LOCAL: Auditório nº 02 da FS/UnB
TITLE:

CORRELATION BETWEEN NATRIURETIC ATRIAL PEPTIDE TYPE B (PRO-BNP) AND ECOSTRAIN EVALUATION IN DUCHENNE AND BECKER MUSCULAR DYSTROFIES IN THE PEDIATRIC AGE GROUP

KEY WORDS:

Duchenne Muscular Dystrophy; Becker Muscular Dystrophy; EcoStrain, Atrial Natriuretic Peptide; Dystrophic cardiomyopathy

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction: Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (DMB) neuromuscular diseases caused by dystrophin deficiency, with DMD being the most frequent in childhood. After the advent of ventilatory interventions and corticosteroid therapy, Dystrophic Cardiomyopathy (CD) became its major cause of mortality in DMD, but the diagnosis is still late due to its poorly symptomatic nature. The active search for CD may enable early cardioprotection and, consequently, a better prognosis, while research in curative therapies advances. Noninvasive imaging has already been consolidated as effective instruments of this evaluation. The validation of serum biomarkers as predictors can help in the detection and stratification of CD risk. Objective: to evaluate the correlation between the Type B Atrial Natriuretic Peptide (Pro-BNP) and the subclinical cardiac alterations measuredby EcoStrain in patients with Duchenne Muscular Dystrophy (DMD) andBecker (DMB) in a reference outpatient clinic for neuromuscular diseases. Methods: observational and analytical study of longitudinal and prospective design with children and adolescents with DMD and DMB followed at the Children's Hospital of Brasilia José Alencar - Federal District - Brazil. Medical records, clinical examination, electrocardiogram, laboratory tests, echocardiogram and Holter were performed, with intervention after the first tests, when indicated, and clinical reassessmentand with tests in two other times, during a mean follow-up of 12 months. Descriptive and association analysis, agreement and correlation was performed through the IBM SPSS (Statistical Package for the Social Sciences) program 23, 2015. The significance level used in the entire study was 5%. Results: The study included 28 boys (27 DMD and 1 DMB), with a mean age of 10.1 years, being more than 70% asymptomatic and without alterations in cardiovascular physical examination, 90% without functional alterations to conventional Echocardiogram and 93.75% with changes in the Longitudinal Global Strain (GLS). The Shortening Fraction (SF) and the Ejection Fraction -Teicholz (LVEF-Tz) decreased significantly throughout the study, the intervention did not change the parameters and there was no agreement between Pro-BNP and SGL, and this analysis was impaired by the absence of normal GLS values in the sample. Conclusions: The EcoStrain detected subclinical myocardial dysfunction in patients who were still very young, and there was no agreement with pro-BNP values. LVEF-Tz and SFdecreased significantly and the intervention did not alter echocardiographic parameters throughout thestudy.

BANKING MEMBERS:
Presidente - 783.299.221-20 - FAYEZ BAHMAD JUNIOR - UnB
Externa à Instituição - LARISSA VILELA PEREIRA - USP
Externo à Instituição - Osório Luís Rangel de Almeida - HBDF
Externo à Instituição - THAÍS GOMES ABRAHÃO ELIAS - UNIFESP