Banca de DEFESA: FELIPE DE QUEIROZ PIRES

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : FELIPE DE QUEIROZ PIRES
DATE: 07/03/2023
TIME: 13:00
LOCAL: : Sala de Reunião 1 - Faculdade de Saúde - Campus Darcy Ribeiro - Universidade de Brasília
TITLE:

Three-dimensional printing on the pharmaceutical field and the application of nanotechnology

KEY WORDS:

3D printing; Nanotechnology; Oral administration; Polymers; Hot Melt Extrusion

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

The use of 3D printing in the pharmaceutical area promises to revolutionize the drug therapy, having the complete customization of the dosage form as one of the main advantages of its use, with emphasis on the fused deposit modeling technique (FDM) that incorporates in its process technologies already used in the pharmaceutical industry, such as hot melt extrusion. With this technology the therapeutic possibilities have been expanded, since changes in the printing parameters can affect important characteristics of the drug, such as dosage and release profile. With the advances in this medicinal application of 3D technology, new aspects of therapy are being developed, such as the combination with other technologies of great impact, like nanotechnology. Nanotechnology has been demonstrating its impact for years in the pharmaceutical area, becoming even more important when polymeric materials associated with drugs are involved, due to the tendency of these materials to spontaneously form nanoparticles under certain dissolution conditions. With this, the present work aims to investigate 3D printing FDM as a reliable way to obtain pharmaceutical dosage forms and its correlation with nanotechnology, either by the spontaneous formation of the nanoparticles or by the inclusion of nanoparticles in formulations that will be printed. The first part of the study evaluated the impact of the 3D printing parameters in obtaining drug prototypes, highlighting the need for validation protocols to incorporate the technology in drug production. The second part of the study investigated the spontaneous formation of nanoparticles by the dissolution of 3D-printed tablets formulated with three different polymers and using naringenin as the model drug. The result demonstrated the formation of the particles in all the tested polymers, encapsulating a considerable amount of the drug, demonstrating the necessity to understand this process as a way to predict how these particles may affect the oral drug absorption. Finally, future perspectives are the incorporation of iron oxide nanoparticles into an oral pharmaceutical form made by 3D printing, investigating their dissolution process and the possibility of their use for the oral treatment of iron deficiency.

BANKING MEMBERS:
Presidente - 1634362 - MARCILIO SERGIO SOARES DA CUNHA FILHO
Externo ao Programa - 1929494 - JOAO PAULO FIGUEIRO LONGO
Externo à Instituição - BRENO NORONHA MATOS - UNIEURO
Externo à Instituição - IDEJAN PADILHA GROSS - UnB
Externo à Instituição - PAULO CESAR DE MORAIS - UCB