Banca de DEFESA: MAIANE SILVA DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MAIANE SILVA DE SOUZA
DATE: 28/02/2023
TIME: 14:00
LOCAL: https://teams.microsoft.com/l/meetup-join/19%3ayJ5zwxYC1k_M86TLZr1Kw9M7wHHTCk0fV9- 4YMZOT01%40thre
TITLE:

DEVELOPMENT OF AN INNOVATIVE DEVICE CONTAINING THYMOL TO COMBAT SARS-COV

KEY WORDS:

SARS-COV. Invading device. Thymol. Microemulsions. DSC test

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

In mid-2020, humanity faced one of the biggest pandemics in its entire history. The pandemic arising from the new coronavirus (COVID-19) has become one of the great challenges of the 21st century. It currently affects more than 100 countries and territories on five continents. Its impact remains invaluable, but directly and/or indirectly affects the health and economies of the world's population. It comprises of an infectious disease caused by the coronavirus related to severe acute respiratory syndrome through the SARS-CoV-2 virus. In 2019, in Wuhan, China, the first case of pneumonia caused by an unknown pathogen was described and reported to health authorities. On January 7, 2020, the first viral genome sequencing results were published and on January 12, China showed that the genetic sequences were shared with countries around the world and with the WHO through the Global Initiative on Sharing Database. All Influenza Data (GISAID). From these diagnoses, cases spread rapidly across the world, initially in mainland Asia, with cases reported in Thailand, Japan and South Korea. The virus was then imported to other countries and continents. Due to its high transmission power, Covid-19 promoted the development of scientific research aimed at studying efficient strategies to combat SARS-COV. In this sense, research has shown a very significant result of the effectiveness of microemulsions against a range of microorganisms, including bacteria, viruses, fungi and yeasts. Therefore, it is important to emphasize the great importance of microtechnology in the pharmaceutical, chemical and biological areas, making it possible to increase the bioavailability of therapeutic molecules, favoring interaction and biological potentiation. In this way, the present work aims to develop an innovative effervescent sanitizing device containing thymol particulate system, through the elaboration of a saponeic base through recycled oil and standardization, preparation of microemulsions, performance of DSC and Mev tests and elaboration of an innovative tablet of physical-chemical quality and microbiological and bacteriological efficiency. The method used in this work was analyzed using the High Performance Liquid Chromatography (HPLC) equipment, with the production of stock solutions in methanol, this solvent was used to enable the dilution of thymol because it is highly soluble in alcohol. Currently, a gap is noticeable regarding the presence of a specific literature regarding the tablet production process which was formulated in this work. Thus, the study was developed by carrying out tests which were chosen for better analysis of the formulations, taking into account the guidelines of the resolution of the collegiate board RDC n 59- 2010, which provides for the procedures and technical requirements of good practices for sanitizing products, the Brazilian Pharmacopoeia 6th Edition in the analyzes for tablets, as well as the scientific literature.

BANKING MEMBERS:
Externo à Instituição - BRENO NORONHA MATOS - UNIEURO
Presidente - 1750177 - LIVIA CRISTINA LIRA DE SA BARRETO
Externo à Instituição - RICARDO FERREIRA NUNES - IESB
Externa à Instituição - TALITA FARAJ FARIA - SARAH