Banca de QUALIFICAÇÃO: Miguel Cesar Merino Ruiz

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : Miguel Cesar Merino Ruiz
DATE: 25/10/2023
TIME: 09:00
LOCAL: Plataforma Zoom
TITLE:

Effect of early deep brain stimulation in the Parkinson's disease rodent model induced by intracerebral infusion of 6-hydroxydopamine

KEY WORDS:

Neuroprotection. DBS. Parkinson's disease. Rodent. 6-OHDA

PAGES: 100
BIG AREA: Outra
AREA: Defesa
SUMMARY:

Invasive neuromodulation through deep brain stimulation (DBS) of cerebral nuclei is currently a well-defined therapeutic strategy for Parkinson's disease treatment. In clinical practice, however, DBS -or other actual treatment strategies- did not halt disease progression. Current scientific evidence shows neuroprotection in the rodent model of Parkinson's disease submitted to DBS in experiments that carried out this approach at least seven days after Parkinsonism induction. In this thesis, we propose invasive neuromodulation using DBS one day after Parkinsonism induction by intracerebral injection of 6-hydroxydopamine (6- OHDA) in mice, searching for motor responses similar to those described in the literature in later models, as well as evidence of neuroprotection

COMMITTEE MEMBERS:
Externa à Instituição - ALESSANDRA MUSSI RIBEIRO - UNIFESP
Externo ao Programa - 3277368 - GABRIEL AVOHAY ALVES CAMPOS - nullPresidente - 2567703 - MARCIA RENATA MORTARI
Externa à Instituição - Perola de Oliveira - SARAH