Influence of diabetes on dental pulp calcification: A systematic review and meta-analysis
diabetes mellitus, pulp calcification, systematic review.
Introduction: Diabetes mellitus is a group of metabolic diseases primarily characterized by hyperglycemia. A series of changes occur in the dental pulp of diabetic patients, including points of calcification. Objective: This systematic review evaluated the influence of diabetes on pulp calcification. Methodology: Searches were conducted in the databases: PubMed, Embase, LILACS, Web of Science, and Google Scholar. Based on the results, studies that assessed the influence of diabetes on pulp calcification were included. The next step was to evaluate the risk of bias using the tools: JBI Appraisal Checklist, SYRCLE’s Risk of Bias, and The Quin. A meta-analysis was performed with three cross-sectional observational studies to assess the prevalence of pulp calcification in diabetic patients compared to the control group. Results: Of the 2,269 studies identified from the databases, 9 studies were included in this systematic review. The included studies involved various types of studies: one in vivo, three in vitro, four observational, and one that combined in vitro and in vivo methodologies. The meta-analysis results indicate that the probability of developing pulp calcification is 5.19 times higher in diabetic patients. Conclusion: It is concluded that diabetes acts as a risk factor for the development of pulp calcification in diabetic patients.