Effect of early deep brain stimulation in the Parkinson's disease rodent model induced by intracerebral infusion of 6-hydroxydopamine
Neuroprotection. DBS. Parkinson's disease. Rodent. 6-OHDA
Invasive neuromodulation through deep brain stimulation (DBS) of cerebral nuclei is currently a well-defined therapeutic strategy for Parkinson's disease treatment. In clinical practice, however, DBS -or other actual treatment strategies- did not halt disease progression. Current scientific evidence shows neuroprotection in the rodent model of Parkinson's disease submitted to DBS in experiments that carried out this approach at least seven days after Parkinsonism induction. In this thesis, we propose invasive neuromodulation using DBS one day after Parkinsonism induction by intracerebral injection of 6-hydroxydopamine (6- OHDA) in mice, searching for motor responses similar to those described in the literature in later models, as well as evidence of neuroprotection