Banca de DEFESA: ANA RACHEL TEIXEIRA BATISTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANA RACHEL TEIXEIRA BATISTA
DATE: 17/08/2022
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

Fraturas morfométricas assintomáticas no hipoparatireoidismo pós-cirúrgico.

KEY WORDS:

“post-surgical hypoparathyroidism; morphometric fracture assessment; trabecular bone score _”

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

“_Introduction: Hypoparathyroidism is a rare disease characterized by a decrease in serum calcium concentration in the presence of low or inappropriately normal parathyroid hormone (PTH) values. The bone manifestations of this disease result from a marked reduction in remodeling, an increase in density and changes in bone microarchitecture. However, the impact of these skeletal abnormalities on fracture risk remains unclear. This study aimed to describe the frequency of morphometric fractures in individuals with post-surgical hypoparathyroidism, and to compare it to a matched control group. We also describe the clinical, laboratory and bone characteristics and the correlations of these parameters in the group with hypoparathyroidism. Method: This was an observational cross-sectional study in which individuals with post-surgical hypoparathyroidism older than 18 years, registered in the calcitriol dispensing protocol of the health department of the Federal District, were included. Results: There were 70 participants with post-surgical hypoparathyroidism, with a mean age of 52.4 years (± 12.2 years), 95.7% (n = 67) women, 60% (n = 42) non-obese and 55.7% (n = 39) were postmenopausal; compared to 66 control subjects matched for sex, age, and body mass index. The group with hypoparathyroidism had significantly lower values of calcium, PTH and magnesium compared to the control group. Phosphorus, calciuria and bone mineral density at all sites were significantly higher when compared to controls. The FRAX® Brazil calculation showed that all individuals had a low risk of fractures. The group with hypoparathyroidism was three times less likely to have low bone mass. Only 2.9% of individuals with hypoparathyroidism had silent fractures, with no statistical difference between the groups. The mean TBS value found was 1,46 in the hypoparathyroid group versus 1,42 in the control group, with no statistical difference between them. Subgroup analysis including postmenopausal women showed that the results found in the total group were reproduced in this population. There was no significant association between any laboratory or bone parameter investigated and VFA, but TBS correlated with BMD and PTH, indicating that higher BMD values and lower PTH values are related to TBS increase. Decreased TBS was also correlated with postmenopausal status and low bone mass. Conclusion: Our results indicate that vertebral fractures are not common in patients with post-surgical hypoparathyroidism, according to the pathophysiological hypotheses and high bone mineral density. The VFA is a reliable method for evaluating vertebral fractures and its application during the densitometry examination should be considered in these patients. The FRAX® tool associated with TBS can predict the individuals most at risk. Future studies are needed to evaluate specific factors associated with vertebral fractures in post-surgical chronic hypoparathyroidism.”

BANKING MEMBERS:
Externa à Instituição - FERNANDA SILVEIRA TAVARES - UCB
Presidente - 2329402 - ANGELICA AMORIM AMATO
Externa à Instituição - LARA BENIGNO PORTO DANTAS - SESDF
Externo à Instituição - LUIZ AUGUSTO CASULARI ROXO DA MOTTA - UnB