Banca de QUALIFICAÇÃO: ELISA GRILLO ARAÚJO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ELISA GRILLO ARAÚJO
DATE: 31/10/2024
TIME: 14:00
LOCAL: Sala de reunião 1
TITLE:

Ozone Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Individuals with Type 2 Diabetes Mellitus Associated Periodontitis

KEY WORDS:

“Ozone; Diabetes Mellitus; Periodontitis; Biomarkers; Immunological Adjuvants; Immunomodulation."

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

“Diabetes mellitus and periodontitis are immunoinflammatory diseases that share a bidirectional relationship, where the chronic state of one can trigger and perpetuate the progression of the other. Periodontitis involves dysbiosis of the oral microbiota, mediated by immune responses, while diabetes mellitus is a group of systemic disorders characterized by hyperglycemia, resulting from dysfunctions in insulin secretion and/or action. The gold-standard treatment for periodontitis, non-surgical scaling and root planing, often fails to achieve the expected clinical outcomes in individuals with diabetes, due to the increased risk of periodontal disease recurrence. Ozone therapy, widely studied for its antimicrobial properties, also offers biomodulation benefits, such as antioxidant, anti-inflammatory, and anti-hypoxic effects, which can be particularly advantageous for patients with diabetes. However, to date, only three studies have evaluated the use of ozone therapy as an adjunct in periodontal treatment for patients with diabetes. Given the scarcity of evidence, we conducted a scoping review to synthesize the effects of ozone therapy as an adjunct treatment for various diabetes-related complications. This review indicated potential benefits of this therapy in managing periodontitis associated with diabetes, leading to the proposal of a protocol for applying ozonized oil as an adjunct to periodontal therapy in patients with type 2 diabetes. This protocol is being tested in a randomized, triple-blind clinical trial currently underway at the dental clinic of the University Hospital of Brasília (HUB), with approval from the Research Ethics Committee of the University of Brasília (CAAE: 51018821.2.0000.0030). The study is evaluating periodontal clinical parameters such as bleeding on probing index, probing depth, and clinical attachment level. Additionally, samples of saliva and crevicular fluid from periodontal pockets (≥ 5 mm) are being collected for future analysis of the microbiome, cytokines, Wnt/β-catenin pathway biomarkers, as well as proteomic and transcriptomic analysis of saliva. ”

COMMITTEE MEMBERS:
Interna - 1889805 - CRISTINE MIRON STEFANI
Externa à Instituição - DANIELA CORREA GRISI
Presidente - ***.490.971-** - LOISE PEDROSA SALLES - UnB
Interno - 1762709 - SERGIO BRUZADELLI MACEDO