Banca de QUALIFICAÇÃO: RAFAELLA CRISTHINA REGO MARQUES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : RAFAELLA CRISTHINA REGO MARQUES
DATE: 25/03/2025
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

Risk factors for root caries and caries activity associated with salivary changes of adults with type 2 diabetes mellitus

KEY WORDS:

Saliva, Hyperglycemia, Dental caries, Root caries, Caries activity, Phosphate, Calcium, Urea, Salivary flow

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

“It is suggested that individuals living with Diabetes Mellitus (DM) have an increased risk of dental caries, and the biological plausibility has been attributed to altered salivary parameters such as salivary pH, salivary flow, and buffering capacity. However, the occurrence of caries in type 2 diabetes (T2D) is not yet fully understood, especially in the elderly population. Objective: To evaluate risk factors among salivary, serum, and dietary parameters for caries activity and root caries in adults with T2D. Materials and Methods: A study was conducted and divided into two analyses: cross-sectional and longitudinal. The analysis involved dentate adults aged 35 years or older, examined in 2023 and 18 months later. The sample size calculation was based on a 2:1 ratio of individuals with DM to those without, resulting in a total of 170 participants. Sociodemographic data and clinical parameters were collected, including years living with T2D, smoking history, salivary pH, salivary flow, buffering capacity, salivary calcium, salivary glucose, salivary phosphorus, and salivary urea, among other variables. The results assessed the number of coronal caries lesions and root caries. Poisson regression models were applied to estimate risk ratios (RR) and 95% confidence intervals (CI). The longitudinal analysis is still awaiting outcome evaluation. Partial Results: In cross-sectional analyses, phosphate was associated with active caries lesions (RR = 1.16; 95% CI = 1.08-1.24; p < 0.001). Considering the total number of root caries lesions, a higher pH was associated with a greater occurrence of root caries (RR = 0.49; 95% CI = 0.30-0.80; p = 0.04). Additionally, in the analysis adjusted for age, smoking, glycemic control, and the number of natural teeth, salivary calcium was associated with a higher number of root caries lesions (RR = 1.07; 95% CI = 1.02-1.11; p = 0.006). Considering only the number of active root caries lesions, higher salivary pH remained associated with a lower number of active caries lesions (RR = 0.43; 95% CI = 0.22-0.85; p = 0.01). Higher urea levels were associated with a lower occurrence of active caries (RR = 0.94; 95% CI = 0.88-0.99; p = 0.04) in the model adjusted for sex, age, smoking, glycemic control, and the number of natural teeth. Conclusion: Our regression models demonstrated which salivary parameters were associated with caries, even when adjusted for T2D. Salivary parameters such as reduced salivary flow alone does not explain the higher number of root caries lesions. We observed that chronic hyperglycemia caused by T2D affected oral health but did not influence the association between coronal caries and salivary phosphate levels, nor between root caries and salivary pH, salivary calcium levels, glucose, and salivary viscosity in T2D patients. More factors are involved in explaining the increased risk of root caries in these individuals, and this association should be evaluated longitudinally.

COMMITTEE MEMBERS:
Externa ao Programa - 1135613 - BRUNA FRIZON GREGGIANIN - nullInterna - 1889805 - CRISTINE MIRON STEFANI
Presidente - 1306536 - NAILE DAME TEIXEIRA
Interna - ***.510.191-** - NICOLE AIMEE RODRIGUES JOSE - UnB