Banca de DEFESA: Danielle Leal Vieira

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : Danielle Leal Vieira
DATE: 28/04/2023
TIME: 09:00
LOCAL: Plataforma Teams
TITLE:

"Evaluation by computed microtomography of changes in bone microarchitecture that occurred in themandible and femoral neck in ovariectomized rats using oral Risedronate"

KEY WORDS:

"Microtomography,Risedronate,osteoporosis, mandiblefemur neck"

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

"Osteoporosis is the most commonmetabolic bone disease and is the leading cause of skeletal fragility fractures. It impacts on individual health, public health and health spending worldwide. Developing diagnostic, prevention and treatment mechanisms are essential, as well as knowing andpredicting their long-term impacts. Thus, evaluating the behavior of anti-resorptive medications widely used for the management and prevention of osteoporosis is necessary to verify bone behavior and its effects. The use of animal protocols contributes tothis elucidation process. Twenty female animals of the WISTAR,were used, divided into 4 groups: Control (CON), Ovariectomized (OVX), Ovariectomized + Risedronate (ORI), Risedronate (RIS). Two computed microtomography scans were performed at different times: 12 weeks after the ovariectomy (T1) and 12 weeks after using oral Risedronate in the mandible and femoral neck (T2). Turkey's test and Pearson's correlation were performed, with a significance of 5%. In the mandible, trabecular bone findings were: in the OVX group, bone mineral density and volume/area were significantly lower; the trabecular space increased in all groups; number of trabeculae increase in OVX and CON, and decrease in ORI and RIS; trabecular separation reduction in RIS, and in ORI and RISporosity reduction. In the mandibular cortical bone, however, there was an increase in mineral density in the ORI group. In the femoral neck, the findings in trabecular bone were: reduced bone mineral density in the OVX group and increased ORI; increased volume/area ratio in RIS; increased trabecular separation only in OVX; porosity only reduction in RIS; and increased trabecular space in the CON, ORI, RIS groups. In relation to the cortical bone, only the trabecular separation showed static increase in allgroups. When evaluating the correlation between sites, only trabecular bone mineral density behaved similarly. It's concluded that Risedronate causes alterations in the bone microstructure in different ways, depending on the site analyzed, more studies evaluating the medication in other sites can collaborate with the elucidation of the behavior and indication of the use of the medication."

BANKING MEMBERS:
Externa ao Programa - 2329402 - ANGELICA AMORIM AMATO
Externa à Instituição - Fabiana Tolentino de Almeida - UniAlberta
Externa à Instituição - MARIA ALVES GARCIA SANTOS SILVA - UFG
Presidente - 2315081 - NILCE SANTOS DE MELO
Interno - 3475960 - PAULO TADEU DE SOUZA FIGUEIREDO