Banca de DEFESA: GUSTAVO GOMES DE LIMA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GUSTAVO GOMES DE LIMA
DATE: 16/12/2024
TIME: 14:00
LOCAL: Sala de reunião 1
TITLE:

“CHEMICAL PROPERTIES OF AH PLUS BIOCERAMIC SEALER AND ITS EFFECT ON OSTEOCLASTOGENESIS: AN IN VITRO STUDY”

KEY WORDS:

“Endodontics; biocompatibility test; chemical properties; root canal filling; osteoclasts; osteoclastogenesis".

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

“Endodontic treatment consists of several fundamental steps, ranging from cleaning and shaping the root canal system to the final obturation phase, steps that are crucial for the long-term success of the treatment. In addition to adequate sealing properties, the root canal filling material must stimulate or induce the repair of the remaining tissues in the root canal systems. In this context, root canal filling cements have evolved in their composition over time, where bioceramic cements have emerged as a significant innovation in stimulating mineralization and osteogenesis. The literature demonstrates a positive interaction of this type of material with the surrounding tissues, contributing to bone repair and regeneration, which is extremely important especially in the treatment of cases diagnosed with necrosis and apical lesion. AH Plus Bioceramic (AHP-BIO) is a bioceramic cement composed mainly of zirconia dioxide and tricalcium silicate that emerged as an improvement of its original formulation, associating the good properties that AH Plus presented with the bioactivity of a bioceramic cement. This cement has in its formulation a low proportion of calcium silicates and the presence of dimethyl sulfoxide and traces of lithium carbonate, changes that can impact its effect. Thus, this study aimed to investigate the biological effect of AHP-BIO, a relatively new material in endodontics. The work was structured in three chapters. The first chapter carried out a review of the literature on bioceramic cements, highlighting their characteristics, composition and advantages for endodontic treatment. The second chapter evaluated the chemical properties of AHP-BIO, revealing its capacity to release calcium ions and maintain an alkaline pH, factors associated with the biocompatibility and mineralizing potential of the material. In the third chapter, the impact of AHPBIO on osteoclastogenesis in RAW 264.7 cell cultures was studied. The results indicated that AHPBIO increased the expression of the TRAP and CATEPSIN genes, involved in the bone resorption process, and inhibited the Wnt pathway with low expression of the c-Myc and MMP-7 proteins. In addition, an increase in the number of multinucleated osteoclasts was observed, suggesting that AHP-BIO stimulates osteoclastic activity. The findings demonstrate the potential of AHP-BIO as an endodontic material, but caution should be exercised in cases requiring osteoclastogenesis control. This study thus contributes to the careful clinical selection of bioceramic cements based on scientific evidence of their properties and biological effects.”

COMMITTEE MEMBERS:
Externo à Instituição - CLEOMAR DONIZETH RODRIGUES - UNICEPLAC
Interno - 4208835 - LAUDIMAR ALVES DE OLIVEIRA
Presidente - ***.490.971-** - LOISE PEDROSA SALLES - UnB
Interna - 3342495 - TAIA MARIA BERTO REZENDE