Banca de DEFESA: CECILIA DE BRITO BARBOSA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CECILIA DE BRITO BARBOSA
DATE: 09/08/2023
TIME: 09:00
LOCAL: Plataforma Teams
TITLE:

"Collagenolytic capacity of Streptococcus mutans and its potential involvement in root caries lesions"

KEY WORDS:

Proteases, Dentin caries, Microbiology, Root caries, S.mutans

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

"Root caries is an incident condition associated with increased life expectancy worldwide and reduced edentulism. Root surfaces are more susceptible to cariogenic challenges than tooth enamel because of their high organic content. Although the action of bacteria in the demineralization phase of caries development is well known, it is not known what their involvement in relation to the degradation phase of the organic matrix. Possibly, they act on collagen fibers exposed after demineralization in the second phase of lesion development (phase of collagen degradation). Several host-derived metalloproteases seem to be involved in this phase and bacterial collagenolytic proteases could also be due to the presence of proteolytic bacteria and expression of collagenase genes already detected at the site. This work aimed to explore the characteristics involved in the second stage (proteolytic) of the process of formation of root caries lesions, with emphasis on the collagenolytic capacity of S. mutans. If their involvement in the development of root caries is confirmed, these collagenases can be explored as a new target for possible treatments in the inhibition of collagenases or even substances that promote cross-linking between fibrils seem to be the future for the prevention of root caries."

COMMITTEE MEMBERS:
Interna - ***.969.020-** - BRUNA GENARI DEGRAZIA - UFRGS
Externa à Instituição - DÉBORA HELLER - UNICRUZ
Externa ao Programa - 1107089 - FABRICIA ARAUJO PEREIRA - nullPresidente - 1306536 - NAILE DAME TEIXEIRA
Externa à Instituição - Paula de Castro Kruly - OUTROS