“EFFECT OF HYPERBARIC OXYGEN AND OZONE ON BONE REPAIR AFTER THE USE OF ZOLEDRONIC ACID: IN VIVO STUDY.”
“Medication-Related Osteonecrosis of the Jaws; Ozone; Hiperbaric Oxygen; Bisphosphonate."
“Bone repair and regeneration are complex and continuous processes throughout life. However, there are acquired clinical conditions in which the bone repair process is compromised. Bone morphology and constitution are altered after the use of medications (anti-resorptives and antiangiogenics) or ionizing radiation, essential for the treatment of certain pathologies such as cancer. Adjunct therapies (hyperbaric oxygen and ozone) that promote the restoration of normal morphology and tissue function and reduce potential damage to the natural bone repair process are interesting in various clinical situations. In light of the above, the present study aims to evaluate the effect of hyperbaric oxygen and ozone on bone repair after the use of zoledronic acid in rats.”