Banca de DEFESA: JOANA RODRIGUES DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JOANA RODRIGUES DA SILVA
DATE: 18/09/2024
TIME: 14:00
LOCAL: Sala de reuniões externa - FS
TITLE:

Characterization of Salivary Fluid in Healthy Adults and Those with Exocrinopathic Diseases, with Emphasis on Diabetes Mellitus.

KEY WORDS:

Saliva, salivary flow, glucose, calcium, inorganic phosphate, Diabetes Mellitus, exocrinopathies

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Introduction: Saliva is a complex biofluid composed of mucinous and serous secretions, containing electrolytes, proteins, peptides, and polynucleotides. It is crucial for oral health and can serve as a diagnostic material due to its ability to reflect local and systemic changes. Therefore, evaluating salivary components is essential for understanding and managing conditions associated with salivary dysfunction. Objective: To characterize salivary fluid in healthy adults and individuals with exocrinopathies. Methods: Two studies were conducted: a systematic review and a cross-sectional study. The systematic review was performed following PRISMA guidelines, with searches conducted across eight databases and grey literature. Methodological quality was assessed using Joanna Briggs Institute tools for observational studies. The cross-sectional study included 170 individuals, of whom 157 underwent saliva testing, with 55 exhibiting glycated hemoglobin (A1c) levels ≥ 6.5%. The clinical parameters examined were salivary flow, salivary pH, buffering capacity, salivary glucose, salivary calcium, and salivary phosphate. Results: The systematic review included 71 observational studies, representing a total of 3,732 healthy individuals and 2,875 with oral or systemic conditions affecting salivary flow (ml/min). Healthy individuals had resting flow values not lower than 0.2 ml/min and stimulated flow values not lower than 0.9 ml/min. In the cross-sectional study, the mean levels of Ca, Pi, and glucose in saliva were 8.71±6.12 mg/dL, 7.17±2.07 mg/dL, and 31.99±15.38 mg/dL for individuals with hyperglycemia. Salivary glucose was negatively correlated with Ca (Rho=-0.42; p=0.000) and positively correlated with Pi (Rho=0.26; p=0.002). Conclusion: The characterization of salivary fluid in healthy adults versus those with exocrinopathies, such as Diabetes Mellitus, reveals significant differences in saliva composition and volume. These differences have important implications for oral health and management of associated conditions. A detailed understanding of saliva in pathological contexts is essential for developing effective prevention and treatment strategies, thereby improving the quality of life for affected patients.

COMMITTEE MEMBERS:
Externa à Instituição - SANDRA LIANA HENZ - UFRGS
Externa ao Programa - ***.155.378-** - DANIELA CORREA GRISI - NÃO INFORMADO
Interna - 2867208 - ELIANA MITSUE TAKESHITA NAKAGAWA
Presidente - 1306536 - NAILE DAME TEIXEIRA