Banca de DEFESA: MELISSA BALLIER PRUDENTE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MELISSA BALLIER PRUDENTE
DATE: 15/10/2024
TIME: 14:00
LOCAL: FS-UnB com transmissão remota
TITLE:

“Dentin adhesive containing chlorhexidine and copaiba nanocapsules”

KEY WORDS:

Metalloproteases, Dentin Adhesives, Nanocapsules, Composite Resins, Chlorhexidine

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

The aim of this study was to develop an adhesive containing microcapsules with chlorhexidine in copaiba oil core (MC-CHXCOP), characterize the particles and evaluate their physicochemical properties. Materials and methods: The formulation of MC-CHXCOP was carried out using Polycaprolactone (0.5 g), chlorhexidine acetate (25 mg), copaiba oil (1100 μl), Span™ 60 (0.19 g), polysorbate 80 ( 0.38 g), ethanol (45 mL), acetone (90 mL) and water (265 mL). The suspension was processed by an open cycle spray dryer, using Aerosil (1.5g) as a drying adjuvant. The particles were measured by laser diffraction and morphological analysis by scanning electron microscopy (SEM). An dentin adhesive was formulated and MC-CHXCOP was added at concentrations of 5% and 10% by weight and a group was kept without particles as a control. The adhesive was evaluated for the degree of conversion (n =3), degradation in solvent (n =3) and microtensile bond strength (n=70). One-way ANOVA, Tukey, Fisher and Paired T Test were used for data analysis. Results: The average diameter of the particles was 1µm. There was no difference in initial hardness between groups (p=0.157). The analysis of the percentage hardness loss showed a difference between the groups (p= 0.002). There was no difference between the groups regarding the degree of conversion (p=0.133). Conclusion: Nanocapsules containing chlorhexidine in copaiba oily core were produced and incorporated into a dental adhesive without interfering with its physicochemical characteristics.

COMMITTEE MEMBERS:
Presidente - ***.969.020-** - BRUNA GENARI DEGRAZIA - UFRGS
Interna - 3493627 - FERNANDA CRISTINA PIMENTEL GARCIA
Interna - 3249597 - RAYSSA FERREIRA ZANATTA
Externa à Instituição - THAÍS YUMI UMEDA SUZUKI - UFMG