Banca de DEFESA: MARIA LUIZA DOS SANTOS STANGHERLIN TAVARES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA LUIZA DOS SANTOS STANGHERLIN TAVARES
DATE: 18/02/2025
TIME: 14:00
LOCAL: Sala interna da Direção da Faculdade de Ciências da Saúde
TITLE:

CYTOKINE EXPRESSION IN CREVICULAR FLUID OF PATIENTS WITH PERIODONTAL DISEASE AND DIABETES MELLITUS. A Systematic Review

KEY WORDS:

Diabetes mellitus type II, Cytokines, Biomarkers; Periodontal disease; Crevicular fluid

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

The literature defines Periodontitis as an infectious disease characterized by inflammatory and irreversible destruction of the tissues that protect, support, and anchor the teeth. The presence of biofilm as an etiological agent and periodontopathogens is necessary, but not sufficient for the development of the disease. The onset and progression of periodontal disease depend on interactions between periodontopathogenic bacteria and the host's immune system. As a result of the host-biofilm interaction, inflammatory mediators including cytokines, chemokines, metabolites, and proteolytic enzymes are released and contribute to tissue damage and bone loss. The hypothesis of this study is that the presence of a large number of cytokines in gingival crevicular fluid has been proposed as potentially useful in the diagnosis or prognostic marker of periodontal destruction. Elevated levels of serum IL-6 and IL-1b have been associated with severe periodontitis, and a role has been suggested for periodontal diseases as potential contributors to general inflammation and the development of systemic diseases such as diabetes mellitus. Objectives: To evaluate whether the increase in biomarker levels in gingival crevicular fluid of adult patients with periodontal disease and diabetes mellitus are related to each other. Methods: A systematic review was conducted in PubMed, Medline, Lilacs, Embase, Web of Science, and gray literature in Google Scholar during the years 2023 and 2024. Inclusion criteria included observational studies that evaluated biomarker levels in gingival crevicular fluid of patients with periodontal disease and diabetes mellitus. Exclusion criteria involved animal studiesThe results indicate the presence of levels of IL6 and IL1 in the crevicular fluid, enabling the use of these markers as aids in the analysis of the degree of periodontal disease involvement.

COMMITTEE MEMBERS:
Externa ao Programa - 1135613 - BRUNA FRIZON GREGGIANIN - nullExterna à Instituição - DANIELA CORREA GRISI - TJDFT
Presidente - 4208835 - LAUDIMAR ALVES DE OLIVEIRA
Externa ao Programa - 1219169 - VALERIA MARTINS DE ARAUJO CARNEIRO - null