Banca de QUALIFICAÇÃO: CAMILLA PEDROSA VIEIRA LIMA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : CAMILLA PEDROSA VIEIRA LIMA
DATE: 31/03/2025
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

“The association between the oral and gut microbiome and its impact on systemic health”

KEY WORDS:

“Diabetes mellitus; type 2 diabetes; arterial hypertension; obesity; overweight; colorectal cancer; bowel disease; oral microbiome; gut microbiome; oral-gut axis, dysbiosis; scoping review"

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

“Microbial communities play important roles in ecosystems or in the hosts they inhabit. They contribute to the general maintenance of vital functions, development, and nutrition and protect against numerous bacteria, viruses, or fungi that can trigger health disruption in humans. Currently, much has been studied about oral bacteria being found in other organs and systems. This fact can be explained by hematogenous routes and/or by microorganisms’ dissipation through swallowing saliva, which raises the hypothesis that microbiomes can circulate throughout the body, causing not only oral alterations but also triggering or aggravating systemic diseases, such as diabetes mellitus (DM), obesity (OB), hypertension (HT) and other non-communicable diseases. The oral microbiome then may act as a reservoir for pathobionts, contributing to or exacerbating these disorders. On the other hand, systemic conditions can change the body’s response - exacerbating the immune system - reflecting in the composition of the oral biome. A better understanding of oral dysbiosis associated with non-communicable diseases development or progression could not only help in elucidating the interaction of the oral pathogens with systemic conditions but also identify possible biomarkers for early diagnosis and prevention. OBJECTIVE: The study is compound of two scoping reviews. The first one, already finished, aims to map the literature regarding oral microbiome changes in people with type 2 DM, OB, or HT compared to those without these conditions. The second, in protocol phase, will investigate what is already known about the bacterial translocation in the oral-gut axis and its potential impact on the development or aggravation of systemic diseases. METHODS: Both reviews are guided by the JBI Manual for Evidence Synthesis and reported according to the PRISMA extension for scoping reviews (PRISMA-ScR). A search strategy was developed and adapted to five databases (Embase, LILACS, PubMed, Scopus, and Web of Science) and grey literature (Google Scholar and ProQuest Dissertation and Thesis). Two reviewers are responsible for individually screened studies for inclusion. Important data from the studies, previously determined by the research group, are compared and analyzed. In the first review the focus was to analyze phylum and genera significantly changed. The protocol for the second review is already published in Open Science Framework (OSF) under the DOI number 10.17605/OSF.IO/XJ4Y2. RESULTS: For the first review 1,452 records were retrieved from databases, 86 from grey literature, and 7 from reference lists. After the screening process, 50 records were included, 28 on type 2 DM, 12 on OB and 8 on HT. Two studies addressed metabolic syndromes. Most studies analyzed the oral microbiome in saliva by using 16S rRNA amplicon sequencing. For the second review, the search strategy is currently being refined. CONCLUSION: At the phylum level, Fusobacteria was enriched in ≥3 studies in people with type 2 DM. Firmicutes enrichment was associated with DM, and OB. Genera enriched in DM comprised Catonella, Leptotrichia, Prevotella, and Rothia. In OB, Aggregatibacter and Prevotella. No microorganisms were significantly relevant for HT. For the second review, there is no conclusion available yet.”

COMMITTEE MEMBERS:
Externo ao Programa - 2941431 - ADRIANO DE ALMEIDA DE LIMA - nullExterna ao Programa - 1135613 - BRUNA FRIZON GREGGIANIN - nullPresidente - 1889805 - CRISTINE MIRON STEFANI
Interna - ***.490.971-** - LOISE PEDROSA SALLES - UnB