Banca de DEFESA: CAROLINA LAGO CARIBÉ

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CAROLINA LAGO CARIBÉ
DATE: 21/07/2023
TIME: 14:00
LOCAL: Plataforma Teams
TITLE:

Botulinum Toxin Type A for Facial Paralysis-Related Asymmetry - A Systematic Review

KEY WORDS:

Botox; type A botulinum toxin; facial paralysis; synkinesis; systematic review

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

This systematic review aimed to evaluate the efficacy of type A botulinum toxin (BTX-A) treatment for the correction or attenuation of facial asymmetries resulting from facial paralysis. The protocol for this study was registered in PROSPERO (CRD42022335626). The development followed the guidelines for systematic reviews (PRISMA 2020). Seven electronic databases and grey literature were searched, along with the reference lists of included articles. The inclusion criteria comprised randomized controlled trials, non-randomized intervention studies, and case series with a minimum of 10 patients, comparing the effects of botulinum toxin use for the treatment of facial asymmetry due to facial paralysis with other therapies involving botulinum toxin or no therapy. After removing duplicate articles, 1340 articles remained, which were read in two phases resulting in the following 18 articles included in this review: six pre- and post-studies, three prospective cohorts, three retrospective cohorts, five randomized controlled trials, and one case series. The methodological quality of the articles was assessed using the Joanna Briggs Institute Critical Appraisal Tools. In all studies included in this review, there was an improvement in facial paralysis symptoms after the use of BTX-A. However, most studies had small sample sizes, limiting the generalizability of the results to a larger population. Furthermore, there were variations in dosage, type of BTX-A used, number of injections, and dose per injection point, which precluded the comparison between studies and to perform a meta-analysis. Based on the studies included in this systematic review, it can be concluded that the use of type A botulinum toxin may be effective in attenuating or correcting facial asymmetry caused by facial paralysis.

COMMITTEE MEMBERS:
Externa à Instituição - CELIA MARISA RIZZATTI BARBOSA - UNICAMP
Externa à Instituição - SAMIRA SALMERON - USP
Presidente - 3437282 - ANDRE FERREIRA LEITE
Interna - 1889805 - CRISTINE MIRON STEFANI