Banca de DEFESA: Lucas da Silva Almeida

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Lucas da Silva Almeida
DATE: 30/03/2023
TIME: 10:00
LOCAL: Ambiente Virtual
TITLE:

Global prevalence of sarcopenia in patients with chronic kidney disease: a systematic review and meta-analysis

KEY WORDS:

Chronic kidney disease; Sarcopenia; Skeletal muscle mass; Muscle strength; Physical performance; Prevalence.

PAGES: 112
BIG AREA: Ciências da Saúde
AREA: Educação Física
SUMMARY:

Operationally defined by the progressive and concomitant loss of strength and muscle mass, sarcopenia has been associated with adverse outcomes in the population with chronic kidney disease (CKD), especially those admitted to renal replacement therapies, such as hemodialysis. CKD is a catabolic disease that contributes to several conditions that favor imbalances between deficiency and muscle synthesis, predisposing the patient to a sarcopenic condition. Although it is a topic of growing interest, information on the global prevalence of sarcopenia across the CKD spectrum has not been previously investigated. Objective: To identify the global prevalence of sarcopenia in patients with CKD in the conservative stage and in those undergoing some type of renal replacement therapy (RRT), through a systematic review and metaanalysis. Methods: Searches were performed in MEDLINE, EMBASE, Web of Science, CINAHL and LILACS databases with no restrictions on language or date of publication. Observational studies were included that reported the prevalence of sarcopenia in patients with CKD in the conservative stage or undergoing some RRT, using the definitions of the European Working Group on Sarcopenia in Older People (EWGSOP), Asian Working Group for Sarcopenia (AWGS), Foundation for the National Institutes of Health Sarcopenia Project (FNIH) and International Working Group on Sarcopenia (IWGS), which are the main consensuses available in the scientific literature today. Meta-analyses were conducted to estimate the prevalence of sarcopenia. Finally, subgroup analyzes were performed to identify a better picture regarding the prevalence of sarcopenia in CKD. The present study was registered in the International Prospective Register of Systematic Reviews, number CRD42020213659. Results: A total of 6.974 articles were found through the search strategies. After applying the eligibility criteria, 109 studies were included in the overall meta-analysis with 31.409 participants. Most studies were in hemodialysis (HD) patients, 49 studies (10.990 patients; 37.3%). Pooled meta-analyses showed that the prevalence of sarcopenia in CKD is 24.8% (95% CI: 20.5−29.4), the EWGSOP was the consensus with the highest number of included studies (36 studies) and was the consensus with the highest prevalence of sarcopenia (30.1%). The highest prevalence results were found in the dialysis population (HD + PD) 31.3% (95% CI: 20.2−43.7; p < 0.00). Followed by 9 patients on HD 28.7% (95% CI: 24.7−32.8; p < 0.00). The sarcopenia trait with the highest prevalence found was low muscle strength 43.8% (95% CI: 33.7−54.1). Conclusion: We identified a high prevalence of sarcopenia in patients with CKD, and it is likely that a higher prevalence of sarcopenia occurs due to the severity of the disease and its prevalence may vary according to the consensus used for its definition.

BANKING MEMBERS:
Externa à Instituição - ALICE SABATINO
Externo à Instituição - HEITOR SIQUEIRA RIBEIRO
Interno - 396869 - RICARDO JACO DE OLIVEIRA
Presidente - 1794344 - RICARDO MORENO LIMA