Banca de DEFESA: SABRINA DA CUNHA CAVALCANTI DE ALMEIDA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : SABRINA DA CUNHA CAVALCANTI DE ALMEIDA
DATE: 10/07/2024
TIME: 08:30
LOCAL: Sala virtual via Teams
TITLE:

ASSOCIATION BETWEEN THE SEVERITY OF COVID-19 SYMPTOMS WITH BODY COMPOSITION AND TESTOSTERONE LEVELS IN MEN UP TO 45 YEARS OF AGE

KEY WORDS:

Testosterone, muscle strength, covid-19, muscle mass, SARS-CoV-2.

PAGES: 50
BIG AREA: Ciências da Saúde
AREA: Educação Física
SUMMARY:

Introduction: The SARS-CoV-2 virus has tropism for the respiratory system and therefore its impacts on this system are extensively studied. However, many advances are being related to damage to other organs, such as the male reproductive system, where the degree of injury is closely related to the severity of the disease. When the virus affects the testicular region, the place becomes a reservoir for the Sars-Cov-2 virus, which can lead to the development of tissue damage. Injuries to the structures that make up the testicles can directly influence testosterone production. In the context of COVID-19, many patients have experienced reduced testosterone, inflammation and loss of muscle tissue, leading to post-infection muscle weakness. However, the reduction in lean mass, strength and testosterone in the months following infection is still poorly understood. Therefore, studying the association between Covid diagnosis and testosterone levels, as well as strength and body composition in men, is essential. Objective: to analyze lean mass, muscle strength, body fat and testosterone concentration in men up to 45 years of age with and without a history of positive diagnosis for COVID-19. Methods: The study is cross-sectional in nature. The sample consisted of 46 men aged up to 45 years with (n=36) and without (n=10) a positive diagnosis for Covid-19. Body composition was analyzed by densitometry (DXA). Muscle strength was assessed with the handgrip test. Testosterone blood concentration was performed in a laboratory outside the university with 30 of the 46 participants. Statistical analysis was performed using the SPSS statistical package (version 25.0). The volunteers were stratified into comparison groups: 1. Without diagnosis and 2. with a positive diagnosis for covid-19; as well as 3. Mild symptoms, and 4. Moderate/severe symptoms. Comparison between groups was performed using the Mann-Whitney U test. Association between the diagnosis and the median (above or below) of the dependent variables was performed using Pearson's chi-square test with Yates' correction when necessary. Odds ratios were calculated when relevant. Results: There was no significant association between the presence of a positive diagnosis and the dependent variables (testosterone, strength, muscle mass and body fat). Volunteers with a positive diagnosis were significantly older (29.7 ± 7.9 vs. 22.8 ± 5.4 years). The severity of symptoms was associated with visceral fat (χ2 with Yates correction = 4.20, p = 0.04), so that 78.6% of volunteers who presented moderate/severe symptoms were above the median amount of fat. A trend towards significance was observed when comparing BMI (p = 0.08) and visceral fat (p = 0.09) between the mild symptoms vs. mild symptom groups. Moderate/severe symptoms (BMI: 24.6 ± 4.8 vs 26.9 ± 5.6 kg/m2; Visceral fat: 10.0 ± 7.2 vs 13.6 ± 7.7 kg), respectively. Conclusion: The severity of Covid-19 symptoms is associated with visceral fat, but does not influence the strength, lean mass and testosterone of individuals who have recovered from the disease for at least 12 months. 

COMMITTEE MEMBERS:
Presidente - ***.598.741-** - MAURÍLIO TIRADENTES DUTRA - UnB
Interno - 1794344 - RICARDO MORENO LIMA
Externo à Instituição - FILIPE DINATO DE LIMA - UNICEUB
Externo à Instituição - MARCIO RABELO MOTA - UNICEUB