This study aims to verify the effects of hippotherapy performed once or twice per week on postural control in the sitting position, on the spatio-temporal parameters of gait, on the functional performance of children and adolescents with cerebral palsy (CP) and to analyze the kinematics of the pelvis on walking on the floor and mounted on horseback, in the different tasks of hippotherapy. Forty-one participants, divided into groups one session per week (G1) and two sessions (G2) participated in an intervention of 24 hippotherapy sessions lasting 30 minutes. Assessments were performed at baseline, after 12 weeks and 24 weeks, using a force platform, the GAITRite system, and the Pediatric Evaluation of Disability Inventory-ComputerAdaptive Test (PEDI-CAT), an inertial measurement sensor (Baiobit). Twenty-four sessions of hippotherapy reduced the velocity of the center of pressure (CoP) in G2 (p = 0.006; effect size 0.24); and in the anteroposterior sway (p = 0.003; effect size 0.45). As for gait, there was a significant increase in speed and step length at fast speed also in G2 (p = 0.019; effect size 0.64 and p= 0.036; effect size 0.25 respectively), as well as a significant reduction in the double support time in the self-selected velocity in G1 (p= 0.033; effect size 0.42), for the kinematics there is a similarity between the curves on the ground floor and in the different tasks. There was improvement in all PEDI-CAT domains (p ≤ 0.001) for both groups. Finally, twenty-four sessions of hippotherapy improve sitting postural control, gait and functional performance in children and adolescents with CP, with greater benefits for the frequency of twice per week.