Banca de DEFESA: Silvio de Paiva da Fonseca

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Silvio de Paiva da Fonseca
DATE: 30/08/2022
TIME: 14:30
LOCAL: plataforma Teams
TITLE:

Analysis of cortisol and prolactin as biomarkers in patients with mild to critical clinical forms of Covid-19: a prospective cohort study

KEY WORDS:

SARS-CoV-2, Covid-19, immune system, endocrine system, cortisol, prolacti

PAGES: 95
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction: Identified thousands of deaths worldwide (SARS) causes of thousands of deaths worldwide, the viruses that cause Agu Respiratory Syndrome have been identified by thousands of deaths worldwide. Three major all-cause outbreaks (HCoVs2) in the latter causes three severe pneumonias in Wuhan, China, later created as SARS-CoV. This was responsible for more than 530 million confirmed cases of deaths and more than 6 million deaths worldwide. With great adjustment by system-2, SARS-CoV uses the angiotensin-converting enzyme receptor to infect 2 humans (ACE2). About 81% of cases are asymptomatic or with mild to moderate symptoms and 14% and 5% with severe or critical symptoms. In CoV infections, the immune system is vital for the control and resolution of infections. Furthermore, the system of important functions seems to improve in SARS-CoV-2 infections, as it can alter the functions of several glands. Cortisol and prolactin are the production of immune responses increasing or the production of glucocorticoids which are the production of glucocorticoids. In this way, a hormonal response influences biological responses as well as the immune system, a crucial role in SARS-CoV-2 infections. Objective: To assess between clinical and pro-infant cortisol conditions the severity of presentation and relationship with diagnosis of Covid-19. Methods: A prospective cohort study was carried out composed of volunteer patients of both sexes, both recruited from health units in the Federal District and with Covid-19 confirmed by RT-PCR. A peripheral blood venipuncture collection was performed after confirmation of the RT-PCR result, for use until the puncture of cortisol and prolactin, the direct chemiluminescence methodology. An analysis of the best variables was performed, a multivariate analysis of investigation of the variables variables, was developed within the set of variables that explain each of the variable data, using the method of A. With the correlated data, the risk of risk of low O2 dependence (<9%) and iii) the risk of needing hospitalization ii) the risk of needing hospitalization ii) As covariates: sex, age, presence of comorbidities, presence of flu-like syndrome/signs and symptoms of Covid-19 (fever, cough, headache, myalgia, coryza, sneezing), presence of dyspnea, presence of ageusia and/or anosmia, presence of fatigue/tiredness. Results: Baseline cortisol was related to one in the odds of normal hospitalization support (9%, with O2.9% ventilatory saturation respectively, and with an increase respectively by 15.7%, 6.7% and 1.9%. Gender, age, age and age were as factors that improved a patient's chances of worsening the prognosis, but also the data worsened. Prolactate did not have a major impact on the baseline outcome of the independent variables Conclusion: The data show that there was no change in the cortisol level of patients with comorbidities and with advancing age.

BANKING MEMBERS:
Presidente - 1010271 - TATIANA KARLA DOS SANTOS BORGES
Interna - 3117323 - FABIOLA CRISTINA RIBEIRO ZUCCHI
Externo ao Programa - 2279074 - GUSTAVO ADOLFO SIERRA ROMERO
Externo à Instituição - GUSTAVO BARCELOS BARRA