Banca de QUALIFICAÇÃO: Fábio Gonçalves da Silva

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : Fábio Gonçalves da Silva
DATE: 16/02/2023
TIME: 15:00
LOCAL: Plataforma Teams
TITLE:

Use of Viral Metagenomics in the Evaluation of Kidney Transplant Recipients

KEY WORDS:

CKD, kidney transplantation, metagenomics, EBV, CMV, HPgV.

PAGES: 58
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Clínica Médica
SPECIALTY: Doenças Infecciosas e Parasitárias
SUMMARY:

Chronic kidney disease (CKD) is a progressive, irreversible clinical manifestation that definitively affects the function and structure of the kidneys, making them unable to filter the blood and can also trigger comorbidities with high lethal potential, mainly of cardiovascular origin. As the disease progresses, the only alternative for patients who progress to renal failure is transplantation. Patients will undergo kidney transplantation, start immunosuppressive therapy before the procedure. After receiving the graft, the recommendation is to start induction therapy with biological agents (mainly in the first months after transplantation) to avoid acute rejection. A problem dealt with by clinicians in the follow-up of kidney transplant patients is the appearance of opportunistic infections and viral reactivations. Considering that in Brazil there are no publications related to the blood virome of kidney transplant patients, and that worldwide studies are scarce, the present study proposes the investigation of the blood virome of patients undergoing kidney transplantation. A total of 87 kidney transplant recipients (52 men and 35 women) treated at the University Hospital de Brasília (Federal District, Brazil) were randomly selected for the study of their viromas. Relative prevalences of 16.12% for CMV, 34.28% for HPgV and 1.05% for EBV were detected. Several studies have observed the prevalence rate of HPgV in patients undergoing organ and tissue transplantation, a recent study associated HPgV infection with a good prognosis for liver transplant patients. The samples that were positive for HPgV will be sequenced and the phylogeny will be built. In view of our findings, we reinforce the relevance of metagenomics as an extremely valuable diagnostic support tool, especially in populations with weakened immune systems, where more exuberant and rare clinical manifestations can be triggered by unexpected etiological agents.

BANKING MEMBERS:
Externo ao Programa - 1875971 - EDUARDO ANTONIO FERREIRA
Interna - 3088161 - JULIANA LOTT DE CARVALHO
Interno - 2001303 - RODRIGO HADDAD
Externo à Instituição - SVETOSLAV NANEV SLAVOV - IB/SP
Externa ao Programa - 2053063 - THAIS ALVES DA COSTA LAMOUNIER