Banca de DEFESA: Ana Luisa Alves Nogueira Barros

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Ana Luisa Alves Nogueira Barros
DATE: 10/03/2023
TIME: 10:00
LOCAL: Programa de Pós-graduação Medicina Tropical - NMT - online Teams
TITLE:

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF THE ANTI-SARS-COV-2 ACTIVITY OF A BIOACTIVE PEPTIDE IDENTIFIED IN THE TRANSCRIPTOME OF FIRE SALAMANDER (SALAMANDRA SALAMANDRA).

KEY WORDS:

Defensin; Peptides; Salamander-salamander; SARS-CoV-2; Urodeles.

PAGES: 63
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Amphibians of the Urodela order, salamanders and newts, comprise a rich source of molecules with bioactive properties, especially those isolated from the secretion excreted in the skin, with antimicrobial, antioxidant, vasoactive properties, modulating the immune system, among others. In 2020, the COVID19 disease pandemic began, caused by the severe acute respiratory syndrome virus coronavirus 2 (SARS-Cov-2), which resulted in thousands of deaths. This highlighted the importance of studies of new substances to guide the production of therapeutic and prophylactic drugs for infectious diseases. Considering this, this work aimed to carry out a literature review regarding molecules from urodels, with emphasis on their biological activities and to synthesize and evaluate the anti-SARS-Cov-2 activity of a peptide identified in the transcriptome of the fire salamander (Salamander salamander). The literature presents several classes of urodelar molecules, especially peptides and alkaloids. The identified and synthesized peptide, defensin SS-1, belongs to the class of defensins and the in silico 3D molecular docking experiment performed between the enzyme-linker complex with Spike WT RBD/hACE2 and the peptide linker demonstrate its interaction with the binding site active. Although further studies are needed, the preliminary impact of SS1 defensin evaluated in silico in assay illustrated its potential as a promising molecule for drug development in the treatment of COVID19 disease.

BANKING MEMBERS:
Presidente - 1553559 - JOSE ROBERTO DE SOUZA DE ALMEIDA LEITE
Interna - 1010271 - TATIANA KARLA DOS SANTOS BORGES
Externo à Instituição - RUBENS FERNANDES
Externa à Instituição - ANDREANNE GOMES VASCONCELOS - UDF