Banca de DEFESA: Vanessa Cavalcante de Sena

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : Vanessa Cavalcante de Sena
DATE: 05/06/2023
TIME: 14:30
LOCAL: Núcleo de Medicina Tropical
TITLE:

Viral Hepatitis C: mortality and multiple-cause-of-death study in the Federal District, Brazil.

KEY WORDS:

Viral Hepatitis C; Mortality; Multiple-cause-of-death.

PAGES: 130
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Clínica Médica
SPECIALTY: Doenças Infecciosas e Parasitárias
SUMMARY:

Research shows that, despite the adoption of a single death certificate model and an exact definition of the underlying cause, mortality statistics are still not completely accurate. Hepatitis C is an inflammation of the liver and its mortality rate is calculated from the underlying cause. This indicator is used to estimate the risk of dying from this disease and scale its magnitude; however, it does not fully reflect the contribution of hepatitis C to mortality, since this pathology is mentioned in the Death Certificate (DC) as an associated cause in many deaths where death is attributed to other underlying causes. Considering that, in the Federal District (DF), from 2017 to 2021, more than 65.1% of deaths of patients with viral hepatitis were attributed to other basic causes, this study was justified by the need to broaden the look at this topic and identify how patients with hepatitis C are dying. This was a descriptive epidemiological study that aimed to describe the deaths with mention of hepatitis C in the DC, of residents in the DF, which occurred in the period from 2006 to 2020. The official, non-nominal databases of the Information System on Mortality. For data extraction and analysis, TabWin, Microsoft Excel and Stata software were used, as well as population estimates from the Federal District Planning Company. For trend analysis, Prais-Winsten linear regression was performed. Between 2006 and 2020, 487 deaths with mention of hepatitis C were recorded. Of these, 229 (47.0%) had hepatitis C as the underlying cause and 258 (53.0%) had hepatitis C only as an associated cause. In the 229 DC in which hepatitis C is registered as the underlying cause, the most frequent consequential causes were “other and unspecified forms of liver cirrhosis”, “septicemia” and “acute, chronic or unspecified liver failure”. In the 258 deaths that had hepatitis C as an associated cause, the most frequent underlying causes were “liver cell carcinoma or malignant neoplasm of the liver, unspecified”, “HIV disease resulting in other infections” and “alcoholic liver cirrhosis”. Mortality rates for hepatitis C as the underlying cause and those for hepatitis C + carcinoma showed stationary trends for the overall coefficient, for males and for the age groups 50 to 69 years and 70 years or older; and decreasing trends for females and the 30-49 age group. Both in the group that had hepatitis C as the underlying cause and in the group that had it as an associated cause, the highest percentage of people were between 50 and 69 years old, male, white and had incomplete higher education. This study showed that hepatitis C was under-measured as the underlying cause of death and also the need to train professionals who fill out the DC and to improve  the rules for selection of the underlying cause and the SCB   system.

BANKING MEMBERS:
Presidente - 235612 - MARIA REGINA FERNANDES DE OLIVEIRA
Interna - 484663 - ELISABETH CARMEN DUARTE
Interno - 1961891 - WILDO NAVEGANTES DE ARAUJO
Externa à Instituição - GERUSA MARIA FIGUEIREDO - USP