Banca de DEFESA: JANET SALLIS NIMOH MENSAH

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JANET SALLIS NIMOH MENSAH
DATE: 07/12/2023
TIME: 09:15
LOCAL: Virtual (teams)
TITLE:

SEROEPIDEMIOLOGICAL SURVEY FOR THE DETECTION OF MEASLES VIRUS ANTIBODIES IN THE ADMINISTRATIVE REGION OF SCIA-ESTRUTURAL, FEDERAL DISTRICT, JUNE-NOVEMBER 2021

KEY WORDS:

antibodies, seroprevalence, vaccination, sero epidemiology, susceptibility, immunity.

PAGES: 116
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Clínica Médica
SPECIALTY: Doenças Infecciosas e Parasitárias
SUMMARY:

Background & objectives: Measles is a highly contagious infectious disease with possible lethal consequences; though, it is preventable through vaccination. Vaccination/immunization has proven to be the most efficient measure in preventing and reducing incident cases and deaths caused by the measles virus amongst the population. This study aims at analyzing the seroprevalence of measles within the SCIA- Estrutural-DF community, and to identify the factors associated with the presence of the virus. Methods: Sero epidemiological survey was conducted with a sample size of 890 individuals. After seeking participants' consent, interviews were conducted, and blood samples were collected for serological testing, employing the ELISA technique, to detect IgG antibodies. The data collected were subsequently processed using the software application Jamovi version 2.3.21 and subjected to analysis through descriptive and Poisson statistical methods. Results: The estimated overall seroprevalence was 633/890 [71.1%; 95% CI: 68.0%-74.0%]. The mean age of the general population was 38.4 years (95% CI 35y-42y), standard deviation 14.5, median age 38 years. Regarding gender, 581/890 (65.3%; 95% CI 62.2-68.4) were female; of these, 417/581 (71.7%; 95% CI: 70.0-73.0) were seropositive. There was a high (83% CI 95%; 80.3-85.7) prevalence of seropositives in the 41-60, and >60 age groups (92.6% CI 95% 90.9%-94.3%)], Statistically analyzed after adjustments, the 0-19 age group had an 18% higher prevalence of antibodies [RP 1.18 CI 1.04-1.33 p= 0.009) when compared to the 20-40 age group, as well as 61% (PR 1.61 95% CI 1.19-2.19, p<0.002)) higher prevalence for the over-60years age group when compared to the 0-19years age group. Conclusion: Actions are required to enhance vaccination coverage among the population of the SCIA-Estrutural AR community and to homogenize the distribution of seropositive individuals across different age groups through proactive immunization. Subsequent studies will be necessary to evaluate the levels of measles antibodies in the studied population, as well as further studies needed to confer the level of antibody titers among the population.

COMMITTEE MEMBERS:
Interno - 1840722 - MAURO NISKIER SANCHEZ
Interno - 1961891 - WILDO NAVEGANTES DE ARAUJO
Externa ao Programa - 1974065 - VANESSA RESENDE NOGUEIRA CRUVINEL - UnBExterno à Instituição - WANDERSON KLEBER DE OLIVEIRA - HFA